The Crystal Structure Elucidation of a Tetrapeptide Analog of Somatostatin DOTA-Phe-D-Trp-Lys-Thr-OMe | Sciact - CRIS-система Института катализа

The Crystal Structure Elucidation of a Tetrapeptide Analog of Somatostatin DOTA-Phe-D-Trp-Lys-Thr-OMe Научная публикация

Журнал

Crystals
, E-ISSN: 2073-4352

Вых. Данные

Год: 2022, Том: 12, Номер: 1, Номер статьи : 12, Страниц : 11 DOI: 10.3390/cryst12010012

Ключевые слова

XRD; analogue; somatostatin; DOTA; PRRT

Авторы

Diusenova Sabina ^1,2 , Arkhipov Sergey ^2,3,4 , Avdeev Dmitry ⁵ , Dorovatovskii Pavel ⁶ , Khachatryan Derenik ⁷ , Lazarenko Vladimir ⁶ , Medvedev Michael ⁸ , Nikolaeva Alena ⁶ , Ovchinnikov Mikhail ⁵ , Sidorova Maria ⁵ , Zubavichus Yan ⁴

Организации

1	Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk, Russia
2	Faculty of Natural Sciences, Department of Solid State Chemistry, Novosibirsk State University, 630090 Novosibirsk, Russia
3	State Research Center of Virology and Biotechnology VECTOR of the Federal Service for Surveillance in Consumer Rights Protection and Human Well-being (FSRI SRC VB VECTOR), 630559 Koltsovo, Russia
4	Synchrotron Radiation Facility SKIF, G.K. Boreskov Institute of Catalysis SB RAS, 630559 Koltsovo, Russia
5	National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, 121552 Moscow, Russia
6	National Research Center, Kurchatov Institute, 123189 Moscow, Russia
7	Institute for Chemical Reagents and High Purity Chemical Substances of NRC, 107076 Moscow, Russia;
8	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia

Информация о финансировании (2)

1	Министерство науки и высшего образования Российской Федерации (с 15 мая 2018)	ГЗ-2021-2023
2	Министерство науки и высшего образования Российской Федерации (с 15 мая 2018)	075-15-2021-1355 (121120100401-9)

Herewith, we report for the first time the crystal structure of tetrapeptide FwKT (Phe-D-Trp-Lys-Thr), which is considered to represent an epitope for biomedically relevant hormone somatostatin. The target molecule was successfully crystalized, solved and refined as a conjugate of the tetrapeptide moiety bearing a protective group DOTA at the N-terminus and methylated at the O-terminus. The combination of a hormone active site and a powerful chelator make the substance a highly prospective targeted drug delivery system, especially for peptide receptor radionuclide therapy (PRRT) applications.

Diusenova S. , Arkhipov S. , Avdeev D. , Dorovatovskii P. , Khachatryan D. , Lazarenko V. , Medvedev M. , Nikolaeva A. , Ovchinnikov M. , Sidorova M. , Zubavichus Y.
The Crystal Structure Elucidation of a Tetrapeptide Analog of Somatostatin DOTA-Phe-D-Trp-Lys-Thr-OMe
Crystals. 2022. V.12. N1. 12 :1-11. DOI: 10.3390/cryst12010012 WOS Scopus РИНЦ CAPlus OpenAlex СКИФ ID

Поступила в редакцию:	17 нояб. 2021 г.
Принята к публикации:	16 дек. 2021 г.
Опубликована online:	22 дек. 2021 г.
Опубликована в печати:	1 янв. 2022 г.

Web of science:	WOS:000758173200001
Scopus:	2-s2.0-85121751393
РИНЦ:	47549257
Chemical Abstracts:	2022:216285
OpenAlex:	W4200335960
СКИФ ID:	508

БД	Цитирований
Scopus	1
РИНЦ	1
Web of science	1
OpenAlex	1