Multivalency-Induced Shape Deformation of Nanoscale Lipid Vesicles: Size-Dependent Membrane Bending Effects | Sciact - CRIS-system of Boreskov Institute of Catalysis

Multivalency-Induced Shape Deformation of Nanoscale Lipid Vesicles: Size-Dependent Membrane Bending Effects Full article

Journal

Journal of Physical Chemistry Letters
ISSN: 1948-7185

Output data

Year: 2022, Volume: 13, Pages: 1480-1488 Pages count : 9 DOI: 10.1021/acs.jpclett.2c00090

Tags

Nutrition, Vesicles, Lipids, Deformation, Organic compounds

Authors

Park Hyeonjin ^1,2,3 , Sut Tun Naw ^1,2 , Yoon Bo Kyeong ⁴ , Zhdanov Vladimir P. ⁵ , Kim Jin Woong ¹ , Cho Nam-Joon ³ , Jackman Joshua A. ^1,2

Affiliations

1	School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
2	Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon 16419, Republic of Korea
3	School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, 637553 Singapore
4	School of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59626, Republic of Korea
5	Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia

Funding (2)

1	National Research Foundation of Korea	2020R1C1C1004385
2	National Research Foundation of Korea	2021R1A4A1032782

The size of membrane-enveloped virus particles, exosomes, and lipid vesicles strongly impacts functional properties in biological and applied contexts. Multivalent ligand–receptor interactions involving nanoparticle shape deformation are critical to such functions, yet the corresponding effect of nanoparticle size remains largely elusive. Herein, using an indirect nanoplasmonic sensing approach, we investigated how the nanoscale size properties of ligand-modified lipid vesicles affect real-time binding interactions, especially vesicle deformation processes, with a receptor-modified, cell membrane-mimicking platform. Together with theoretical analyses, our findings reveal a pronounced, size-dependent transition in the membrane bending properties of nanoscale lipid vesicles between 60 and 180 nm in diameter. For smaller vesicles, a large membrane bending energy enhanced vesicle stiffness while the osmotic pressure energy was the dominant modulating factor for larger, less stiff vesicles. These findings advance our fundamental understanding of how nanoparticle size affects multivalency-induced nanoparticle shape deformation and can provide guidance for the design of biomimetic nanoparticles with tailored nanomechanical properties. https://pubs.acs.org/doi/10.1021/acs.jpclett.2c00090?goto=supporting-info

Park H. , Sut T.N. , Yoon B.K. , Zhdanov V.P. , Kim J.W. , Cho N-J. , Jackman J.A.
Multivalency-Induced Shape Deformation of Nanoscale Lipid Vesicles: Size-Dependent Membrane Bending Effects
Journal of Physical Chemistry Letters. 2022. V.13. P.1480-1488. DOI: 10.1021/acs.jpclett.2c00090 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Jan 12, 2022
Accepted:	Feb 3, 2022
Published online:	Feb 7, 2022
Published print:	Feb 17, 2022

Web of science:	WOS:000757522900014
Scopus:	2-s2.0-85124805176
Elibrary:	48151089
Chemical Abstracts:	2022:282348
PMID:	35129365
OpenAlex:	W4210885555

DB	Citing
Scopus	8
Web of science	8
Elibrary	5
OpenAlex	7