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Reactivity vs. Selectivity of Biomimetic Catalyst Systems of the Fe(PDP) Family through the Nature and Spin State of the Active Iron-Oxygen Species Full article

Journal Chemical Record
ISSN: 1527-8999 , E-ISSN: 1528-0691
Output data Year: 2022, Volume: 22, Number: 5, Article number : e202100334, Pages count : 18 DOI: 10.1002/tcr.202100334
Tags C H activation, homogeneous catalysis, iron, reaction mechanism, selective oxidation
Authors Zima Alexandra M. 1 , Lyakin Oleg Y. 1 , Bryliakova Anna A. 2,3 , Babushkin Dmitrii E. 1 , Bryliakov Konstantin P. 1 , Talsi Evgenii P. 1
Affiliations
1 Boreskov Institute of Catalysis, Pr. Lavrentieva 5, Novosibirsk 630090, Russia
2 Novosibirsk State University, Pirogova 1, Novosibirsk 630090,
3 Novosibirsk R&D Center, Inzhenernaya 20, Novosibirsk 630090,

Funding (1)

1 Ministry of Science and Higher Education of the Russian Federation 0239-2021-0009

Abstract: Catalytic approaches to late-stage creation of new C−O bonds, especially via oxygenation of particular C−H groups in complex organic molecules, provide challenging tools for the synthesis of biologically active compounds and candidate drugs. In the last decade, significant efforts were invested in designing bioinspired iron based catalyst systems, capable of conducting selective oxidations of organic compounds. The key role of the oxygen-transferring high-valent iron-oxygen species in selective oxygenation is now well established; the next logical step would be gaining insight into the factors governing the oxidation chemo- and stereoselectivity, in relation to the peculiarities of their electronic structure, which would allow introducing the desired level of predictability into those catalytic transformations. In this Personal Account we analyze recent data on the reactivity of bioinspired formally oxoiron(V) catalytically active sites toward organic substrates having C=C and C(sp3)−H groups. While the majority of reported oxoiron(V) active species are low-spin (S=1/2) complexes, the presence of strong electron-donating groups (NR1R2) in the ligand backbone favors the high-spin (S=3/2) ground state. Remarkably, the high-spin perferryl species exhibit higher chemo-, regio-, and stereoselectivity in the oxidations than their low-spin counterparts, thus witnessing the significance of these subtle electronic effects for the selectivity of oxidations conducted by bioinspired catalysts of the Fe(PDP) family.
Cite: Zima A.M. , Lyakin O.Y. , Bryliakova A.A. , Babushkin D.E. , Bryliakov K.P. , Talsi E.P.
Reactivity vs. Selectivity of Biomimetic Catalyst Systems of the Fe(PDP) Family through the Nature and Spin State of the Active Iron-Oxygen Species
Chemical Record. 2022. V.22. N5. e202100334 :1-18. DOI: 10.1002/tcr.202100334 WOS Scopus РИНЦ AN PMID OpenAlex
Dates:
Submitted: Dec 22, 2021
Accepted: Jan 21, 2022
Published online: Feb 10, 2022
Published print: May 22, 2022
Identifiers:
Web of science: WOS:000753462500001
Scopus: 2-s2.0-85124754254
Elibrary: 48150643
Chemical Abstracts: 2022:333827
PMID: 35142426
OpenAlex: W4211047477
Citing:
DB Citing
Scopus 8
Web of science 9
Elibrary 7
OpenAlex 11
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