Synthesis of Nonselective Sorbents Modified with Carbon Nanomaterials and Their Hemocompatibility | Sciact - CRIS-system of Boreskov Institute of Catalysis

Synthesis of Nonselective Sorbents Modified with Carbon Nanomaterials and Their Hemocompatibility Full article

Journal

Nanobiotechnology Reports
ISSN: 2635-1676 , E-ISSN: 2635-1684

Output data

Year: 2022, Volume: 17, Number: 2, Pages: 219-226 Pages count : 8 DOI: 10.1134/s2635167622020136

Tags

Alumina; Biocompatibility; Blood; Carbon nanofibers; Nitric oxide; Polydimethylsiloxane; Silicones; Single-walled carbon nanotubes (SWCN); Sorbents

Authors

Lykov A.P. ^1,2 , Opoku M. ³ , Rachkovskaya L.N. ¹ , Surovtseva M.A. ¹ , Bondarenko N.A. ¹ , Kim I.I. ¹ , Rachkovsky E.E. ¹ , Volodin A.M. ⁴ , Poveshchenko O.V. ¹

Affiliations

1	Research Institute of Clinical and Experimental Lymphology, Branch of Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk
2	Novosibirsk Research Institute of Tuberculosis, Ministry of Health of the Russian Federation, Novosibirsk
3	Novosibirsk State University, Novosibirsk
4	Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk

A search for promising nonselective sorbents based on composite materials, including using carbon nanomaterials, is an urgent task of resuscitation and toxicology. The synthesis and estimation of the biocompatibility of sorbents based on gamma-aluminum oxide and polydimethylsiloxane, modified with single-walled carbon nanotubes or carbon nanofibers, are carried out. It is detected that the synthesized sorbents adsorb low and medium molecular weight substances on their surface. Moreover, it is found that there is a toxic effect on red blood cells (hemolysis) occurs with prolonged exposure (120 h), short-term (5 min) exposure of the components of human peripheral blood with the sorbents leads to a loss in the number of platelets and leukocytes, mainly granulocytes, of mononuclear cells of the peripheral blood, as well as short-term and long-term contact of the blood components with the samples of sorbents contributes to a decrease in the metabolic activity of the cells and the activation of nitric-oxide production. Based on the results obtained, it can be assumed that the sorbent based on γ aluminum oxide and polydimethylsiloxane, modified with carbon nanomaterials, is promising for the development of nonselective sorbents

Lykov A.P. , Opoku M. , Rachkovskaya L.N. , Surovtseva M.A. , Bondarenko N.A. , Kim I.I. , Rachkovsky E.E. , Volodin A.M. , Poveshchenko O.V.
Synthesis of Nonselective Sorbents Modified with Carbon Nanomaterials and Their Hemocompatibility
Nanobiotechnology Reports. 2022. V.17. N2. P.219-226. DOI: 10.1134/s2635167622020136 WOS Scopus РИНЦ ANCAN OpenAlex

Лыков А.П. , Опоку М. , Рачковская Л.Н. , Суровцева М.А. , Бондаренко Н.А. , Ким И.И. , Рачковский Э.Э. , Володин А.М. , Повещенко О.В.
Синтез неселективных сорбентов, модифицированных углеродными наноматериалами, и их гемосовместимость
Российские нанотехнологии. 2022. Т.17. №2. С.252-260. DOI: 10.56304/s1992722322020133 РИНЦ OpenAlex

Submitted:	May 13, 2021
Accepted:	Jun 29, 2021
Published print:	Apr 1, 2022
Published online:	May 21, 2022

Web of science:	WOS:000799752800011
Scopus:	2-s2.0-85130357696
Elibrary:	48585994
Chemical Abstracts:	2023:67336
Chemical Abstracts (print):	181:362813
OpenAlex:	W4281256978

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