DFT Insights into Superelectrophilic Activation of α,β-Unsaturated Nitriles and Ketones in Superacids Научная публикация
| Журнал |
Organic and Biomolecular Chemistry
ISSN: 1477-0520 , E-ISSN: 1477-0539 |
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| Вых. Данные | Год: 2022, Том: 20, Номер: 34, Страницы: 6799-6808 Страниц : 10 DOI: 10.1039/d2ob01141g | ||||
| Ключевые слова | N-ARYL AMIDES; CATALYZED-REACTIONS; INTRAMOLECULAR CYCLIZATION; AROMATIC-COMPOUNDS; CARBONYL-COMPOUNDS; HOUBEN-HOESCHH-ZEOLITE; ACIDS; 1-PHENYL-2-PROPEN-1-ONES; CHLOROALUMINATE | ||||
| Авторы |
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| Организации |
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Информация о финансировании (2)
| 1 | Министерство науки и высшего образования Российской Федерации (с 15 мая 2018) | 0239-2021-0009 |
| 2 | Министерство науки и высшего образования Российской Федерации (с 15 мая 2018) | 0238-2021-0007 (АААА-А21-121011490019-9) |
Реферат:
Superelectrophilic activation of α,β-unsaturated carbonyl compounds and their isoelectronic analogs, proceeding normally under superacidic conditions, have led to a great variety of beneficial synthetic transformations. However, the essence of such activation is not yet fully recognized, while a number of alternative views on the subject have been discussed at length in the literature. Here, taking the example of virtual reactions of cinnamonitrile and benzalacetone with benzene, their feasible mechanistic variants, including multiple protonation (coordination to AlCl3) of the reactants, were analyzed based on density functional theory (DFT). It is revealed that the most plausible reaction pathways involve the initial N- or O-protonation (coordination to AlCl3) of the activated compounds followed by subsequent protonation on the α-C-atom. Dicationic superelectrophiles thus formed ensure practically barrier-free reactions with benzene in addition to a more favorable energetic profile of their generating, which is in marked contrast to other potential reaction pathways.
Библиографическая ссылка:
Genaev A.M.
, Salnikov G.E.
, Koltunov K.Y.
DFT Insights into Superelectrophilic Activation of α,β-Unsaturated Nitriles and Ketones in Superacids
Organic and Biomolecular Chemistry. 2022. V.20. N34. P.6799-6808. DOI: 10.1039/d2ob01141g WOS Scopus РИНЦ CAPlusCA PMID OpenAlex
DFT Insights into Superelectrophilic Activation of α,β-Unsaturated Nitriles and Ketones in Superacids
Organic and Biomolecular Chemistry. 2022. V.20. N34. P.6799-6808. DOI: 10.1039/d2ob01141g WOS Scopus РИНЦ CAPlusCA PMID OpenAlex
Даты:
| Поступила в редакцию: | 24 июн. 2022 г. |
| Принята к публикации: | 3 авг. 2022 г. |
| Опубликована online: | 6 авг. 2022 г. |
| Опубликована в печати: | 1 сент. 2022 г. |
Идентификаторы БД:
| Web of science: | WOS:000839581200001 |
| Scopus: | 2-s2.0-85136317992 |
| РИНЦ: | 50357031 |
| Chemical Abstracts: | 2022:2116738 |
| Chemical Abstracts (print): | 180:11595 |
| PMID (PubMed): | 35959855 |
| OpenAlex: | W4290000641 |