Direct Comparison Between Apparent Diffusion Coefficient and Macromolecular Proton Fraction as Quantitative Biomarkers of the Human Fetal Brain Maturation | Sciact - CRIS-system of Boreskov Institute of Catalysis

Direct Comparison Between Apparent Diffusion Coefficient and Macromolecular Proton Fraction as Quantitative Biomarkers of the Human Fetal Brain Maturation Full article

Journal

Journal Of Magnetic Resonance Imaging
ISSN: 1053-1807 , E-ISSN: 1522-2586

Output data

Year: 2019, Volume: 50, Number: 1, Pages: 52-61 Pages count : 10 DOI: 10.1002/jmri.26635

Authors

Korostyshevskaya Alexandra M. ¹ , Prihod’ko Irina Yu. ¹ , Savelov Andrey A. ¹ , Yarnykh Vasily L. ^2,3

Affiliations

1	Institute "International Tomography Center" of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation;
2	University of Washington, Department of Radiology, Seattle, Washington, USA
3	Research Institute of Biology and Biophysics, Tomsk State University,Tomsk, Russian Federation

Background: Apparent diffusion coefficient (ADC) is known as a quantitative biomarker of prenatal brain maturation. Fast macromolecular proton fraction (MPF) mapping is an emerging method for quantitative assessment of myelination that was recently adapted to fetal MRI. Purpose: To compare the capability of ADC and MPF to quantify the normal fetal brain development. Study type: Prospective. Population: Forty-two human fetuses in utero (gestational age [GA] = 27.7 ± 6.0, range 20-38 weeks). Field strength/sequence: 1.5 T; diffusion-weighted single-shot echo-planar spin-echo with five b-values for ADC mapping; spoiled multishot echo-planar gradient-echo with T1 , proton density, and magnetization transfer contrast weightings for single-point MPF mapping. Assessment: Two operators measured ADC and MPF in the medulla, pons, cerebellum, thalamus, and frontal, occipital, and temporal cerebral white matter (WM). Statistical tests: Mixed repeated-measures analysis of variance (ANOVA) with the factors of pregnancy trimester and brain structure; Pearson correlation coefficient (r); Hotelling-Williams test to compare strengths of correlations. Results: From the 2nd to 3rd trimester, ADC significantly decreased in the thalamus and cerebellum (P < 0.005). MPF significantly increased in the medulla, pons, thalamus, and cerebellum (P < 0.005). Cerebral WM had significantly higher ADC and lower MPF compared with the medulla and pons in both trimesters. MPF (r range 0.83, 0.89, P < 0.001) and ADC (r range -0.43, -0.75, P ≤ 0.004) significantly correlated with GA and each other (r range -0.32, -0.60, P ≤ 0.04) in the medulla, pons, thalamus, and cerebellum. No significant correlations or distinctions between regions and trimesters were observed for cerebral WM (P range 0.1-0.75). Correlations with GA were significantly stronger for MPF compared with ADC in the medulla, pons, and cerebellum (Hotelling-Williams test, P < 0.003) and similar in the thalamus. Structure-averaged MPF and ADC values strongly correlated (r = 0.95, P < 0.001).

Korostyshevskaya A.M. , Prihod’ko I.Y. , Savelov A.A. , Yarnykh V.L.
Direct Comparison Between Apparent Diffusion Coefficient and Macromolecular Proton Fraction as Quantitative Biomarkers of the Human Fetal Brain Maturation
Journal Of Magnetic Resonance Imaging. 2019. V.50. N1. P.52-61. DOI: 10.1002/jmri.26635 WOS Scopus PMID OpenAlex

Published online:

Jan 11, 2019

Web of science:	WOS:000471831600004
Scopus:	2-s2.0-85059912385
PMID:	30635965
OpenAlex:	W2910088319

DB	Citing
OpenAlex	32
Scopus	25
Web of science	21