Synthesis and Antiviral Properties of Tricyclic Amides Derived from α-Humulene and β-Caryophyllene | Sciact - CRIS-system of Boreskov Institute of Catalysis

Synthesis and Antiviral Properties of Tricyclic Amides Derived from α-Humulene and β-Caryophyllene Full article

Journal

Mendeleev Communications
ISSN: 0959-9436 , E-ISSN: 1364-551X

Output data

Year: 2022, Volume: 32, Number: 5, Pages: 609-611 Pages count : 3 DOI: 10.1016/j.mencom.2022.09.013

Authors

Yarovaya Olga I. ¹ , Kovaleva Kseniya S. ¹ , Borisevich Sophia S. ² , Rybalova Tatyana V. ¹ , Gatilov Yuriy V. ¹ , Sinegubova Ekaterina O. ³ , Volobueva Alexandrina S. ³ , Zarubaev Vladimir V. ³ , Salakhutdinov Nariman F. ¹

Affiliations

1	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation
2	Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, 450054 Ufa, Russian Federation
3	St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russian Federation

The Ritter reaction of humulene with acetonitrile occurs as the biomimetic process to afford the amide having the skeleton of a natural alcohol. The structures of the amides obtained from humulene and caryophyllene were confirmed by XRD data. The activity of some cage compounds against influenza virus allowed one to suggest the mechanism of antiviral action based on interfering with membrane fusion activity of viral hemagglutinin.

Yarovaya O.I. , Kovaleva K.S. , Borisevich S.S. , Rybalova T.V. , Gatilov Y.V. , Sinegubova E.O. , Volobueva A.S. , Zarubaev V.V. , Salakhutdinov N.F.
Synthesis and Antiviral Properties of Tricyclic Amides Derived from α-Humulene and β-Caryophyllene
Mendeleev Communications. 2022. V.32. N5. P.609-611. DOI: 10.1016/j.mencom.2022.09.013 WOS Scopus ANCAN OpenAlex

Submitted:	Feb 28, 2022
Published print:	Oct 1, 2022
Published online:	Oct 6, 2022

Web of science:	WOS:000874166100013
Scopus:	2-s2.0-85139328869
Chemical Abstracts:	2022:2621279
Chemical Abstracts (print):	180:302872
OpenAlex:	W4302759495

DB	Citing
OpenAlex	5
Scopus	3
Web of science	2