Manganese Oxide Nanoparticles: The Influence of Manganese Oxidation State on Selective Lysis of Tumor Cells | Sciact - CRIS-system of Boreskov Institute of Catalysis

Manganese Oxide Nanoparticles: The Influence of Manganese Oxidation State on Selective Lysis of Tumor Cells Full article

Journal

Journal of Nanoparticle Research
ISSN: 1388-0764 , E-ISSN: 1572-896X

Output data

Year: 2023, Volume: 25, Number: 7, Article number : 140, Pages count : 9 DOI: 10.1007/s11051-023-05782-7

Tags

Nanoparticles · Manganese oxides · Selective oncolysis · Human tumor cells · Redox mechanism

Authors

Razumov Ivan ^1,3 , Troitskii Sergei ² , Solovieva Olga ^1,3 , Suprun Evgenii ²

Affiliations

1	Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia
2	Federal Research Center Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia
3	Novosibirsk State University, Novosibirsk 630090, Russia

Funding (2)

1	Ministry of Science and Higher Education of the Russian Federation	0324-2019-0041 (RFMEFI62119X0023)
2	Ministry of Science and Higher Education of the Russian Federation	FWNR-2022-0023

Further studies on the mechanism of intracellular induction of active oxygen species and selective oncolysis with metal oxide nanoparticles (NPs), as well as the discussion of alternative mechanisms of the NPs impact on tumor cells, are needed to introduce nanotechnologies into antitumor therapy. The paper concerns the inhibition of oxidation processes in tumor cells under the action of manganese oxide-based NPs (size 10–60 nm) as the mechanism of a tumor cell death. When manganese (II) hydroxide-based NPs enter the cells, they are oxidized with oxygen to Mn4+ compounds; the oxidation processes being blocked in the tumor cells. Hence, the MnO NPs cytotoxicity can be due to the possible direct reduction of O2 in the presence of manganese compounds in the cells.

Razumov I. , Troitskii S. , Solovieva O. , Suprun E.
Manganese Oxide Nanoparticles: The Influence of Manganese Oxidation State on Selective Lysis of Tumor Cells
Journal of Nanoparticle Research. 2023. V.25. N7. 140 :1-9. DOI: 10.1007/s11051-023-05782-7 WOS Scopus РИНЦ ANCAN OpenAlex

Submitted:	Aug 25, 2022
Accepted:	Jun 5, 2023
Published print:	Jul 1, 2023
Published online:	Jul 1, 2023

Web of science:	WOS:001022368700002
Scopus:	2-s2.0-85163857059
Elibrary:	54385560
Chemical Abstracts:	2023:1429919
Chemical Abstracts (print):	183:274371
OpenAlex:	W4382795807

DB	Citing
OpenAlex	2
Scopus	2
Web of science	2
Elibrary	1