Synthetic Approaches for 15N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for 15N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields | Sciact - CRIS-система Института катализа

Synthetic Approaches for 15N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for 15N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields Иное

Журнал

Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765

Вых. Данные

Год: 2021, Том: 27, Номер: 38, Страницы: 9727 Страниц : 1 DOI: 10.1002/chem.202183862

Ключевые слова

Hyperpolarization, magnetic resonance imaging, NMR spectroscopy , parahydrogen , spectroscopy

Авторы

Chukanov Nikita V. ^1,2 , Shchepin Roman V. ³ , Joshi Sameer M. ⁴ , Kabir Mohammad S.H. ⁴ , Salnikov Oleg G. ^1,2,5 , Svyatova Alexandra ^1,2 , Koptyug Igor V. ¹ , Gelovani Juri G. ^4,6 , Chekmenev Eduard Y. ^4,7

Организации

1	International Tomography Center, SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia
2	Department of Natural Sciences, Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia
3	Department of Chemistry, South Dakota School of Mines & Technology, Rapid City SD 57701, USA
4	Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States
5	Boreskov Institute of Catalysis SB RAS, Acad. Lavrentiev Prospekt 5, 630090 Novosibirsk, Russia
6	College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
7	Russian Academy of Sciences (RAS), Leninskiy Prospekt 14, 119991 Moscow, Russia

Signal amplification by reversible exchange enables efficient nitrogen-15 hyperpolarization of a wide range of bio-compatible substrates by using microtesla magnetic fields. This process is enabled by simulatenous exchange of parahydrogen (the source of polarization) and the N-containing biocompatible molecule to be hyperpolarized.

Chukanov N.V. , Shchepin R.V. , Joshi S.M. , Kabir M.S.H. , Salnikov O.G. , Svyatova A. , Koptyug I.V. , Gelovani J.G. , Chekmenev E.Y.
Synthetic Approaches for 15N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for 15N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields
Chemistry - A European Journal. 2021. V.27. N38. P.9727. DOI: 10.1002/chem.202183862 РИНЦ CAPlus OpenAlex

РИНЦ:	70276387
Chemical Abstracts:	2021:1634873
OpenAlex:	W4212868303

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