Food, Drug and Model Mix Analysis by Organic Monolithic Columns Based on Heterocyclic Monomers Full article
| Journal |
Journal of Liquid Chromatography & Related Technologies
ISSN: 1082-6076 , E-ISSN: 1520-572X |
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| Output data | Year: 2023, Volume: 46, Number: 11-15, Pages: 211-217 Pages count : 7 DOI: 10.1080/10826076.2023.2235402 | ||||
| Tags | HPLC; macromolecules separating; mixed-mode chromatography; monolithic columns; porous polymer | ||||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Ministry of Science and Higher Education of the Russian Federation | 0239-2021-0003 |
Abstract:
This paper presents examples of separation on monolithic columns prepared by two different methods: copolymerization and post-modification. In the first method, monoliths were prepared from styrene, divinylbenzene, and heterocyclic nitrogen-containing monomers. In the second, a styrene/divinylbenzene/4-vinylbenzyl chloride copolymer was obtained and in situ modified with 1-methylimidazole. It has been shown that monolithic columns are capable of separating macromolecules and low-molecular compounds. A comparison was made between a styrene/divinylbenzene/1-vinylimidazole copolymer column and a ProSwift™ RP-3U monolithic column. It has been established that a monolithic column based on 1-vinylimidazole is capable of separating proteins and low molecular weight test substances. However, the ProSwift™ RP-3U column is only capable of separating proteins. Separation examples are given: a test mixture of proteins, natural milk proteins, carbohydrates and drugs on a column with a sorbent based on styrene/divinylbenzene. A modified column was used to study the content of salicylic acid in medicinal preparations containing acetylsalicylic acid.
Cite:
Sotnikova Y.S.
, Patrushev Y.V.
Food, Drug and Model Mix Analysis by Organic Monolithic Columns Based on Heterocyclic Monomers
Journal of Liquid Chromatography & Related Technologies. 2023. V.46. N11-15. P.211-217. DOI: 10.1080/10826076.2023.2235402 WOS Scopus РИНЦ AN OpenAlex
Food, Drug and Model Mix Analysis by Organic Monolithic Columns Based on Heterocyclic Monomers
Journal of Liquid Chromatography & Related Technologies. 2023. V.46. N11-15. P.211-217. DOI: 10.1080/10826076.2023.2235402 WOS Scopus РИНЦ AN OpenAlex
Dates:
| Published online: | Jul 17, 2023 |
Identifiers:
| Web of science: | WOS:001031294400001 |
| Scopus: | 2-s2.0-85165259456 |
| Elibrary: | 54919933 |
| Chemical Abstracts: | 2023:1511542 |
| OpenAlex: | W4384500432 |