Combined Homogeneous and Heterogeneous Hydrogenation to Yield Catalyst-Free Solutions of Parahydrogen-Hyperpolarized [1-13C]succinate | Sciact - CRIS-system of Boreskov Institute of Catalysis

Combined Homogeneous and Heterogeneous Hydrogenation to Yield Catalyst-Free Solutions of Parahydrogen-Hyperpolarized [1-13C]succinate Full article

Journal

Chemical Communications
ISSN: 1359-7345 , E-ISSN: 1364-548X

Output data

Year: 2023, Volume: 59, Number: 62, Pages: 9509-9512 Pages count : 4 DOI: 10.1039/d3cc01803b

Tags

INDUCED POLARIZATION; IN-VIVO; C-13; ORDER; METABOLISM; CONVERSION; FUMARATE; ACID

Authors

Eills James ^1,2,3 , Picazo-Frutos Román ^2,3 , Burueva Dudari B. ⁴ , Kovtunova Larisa M. ^4,5 , Azagra Marc ¹ , Marco-Rius Irene ¹ , Budker Dmitry ^2,3,6 , Koptyug Igor V. ⁴

Affiliations

1	Institute for Bioengineering of Catalonia, Barcelona Institute of Science and Technology, Barcelona 08028, Spain
2	Helmholtz-Institut Mainz, GSI Helmholtzzentrum für Schwerionenforschung, Mainz 55128, Germany
3	Institute for Physics, Johannes Gutenberg-Universität Mainz, Mainz 55099, Germany
4	International Tomography Center SB RAS, Novosibirsk 630090, Russia
5	Boreskov Institute of Catalysis SB RAS, Novosibirsk 630090, Russia
6	Department of Physics, University of California, Berkeley, CA 94720-7300, USA

Funding (7)

1	Russian Science Foundation	22-43-04426
2	German Research Foundation	465084791
3	European Commission	766402 H2020-MSCA-ITN-2017 ZULF
4	European Commission	101063517
5	Ministry of Science and Innovation	RYC2020-029099-I
6	Ministry of Science and Innovation	PID2020-117859RAI00
7	European Commission	GA-863037

We show that catalyst-free aqueous solutions of hyperpolarized [1-13C]succinate can be produced using parahydrogen-induced polarization (PHIP) and a combination of homogeneous and heterogeneous catalytic hydrogenation reactions. We generate hyperpolarized [1-13C]fumarate via PHIP using para-enriched hydrogen gas with a homogeneous ruthenium catalyst, and subsequently remove the toxic catalyst and reaction side products via a purification procedure. Following this, we perform a second hydrogenation reaction using normal hydrogen gas to convert the fumarate into succinate using a solid Pd/Al2O3 catalyst. This inexpensive polarization protocol has a turnover time of a few minutes, and represents a major advance for in vivo applications of [1-13C]succinate as a hyperpolarized contrast agent.

Eills J. , Picazo-Frutos R. , Burueva D.B. , Kovtunova L.M. , Azagra M. , Marco-Rius I. , Budker D. , Koptyug I.V.
Combined Homogeneous and Heterogeneous Hydrogenation to Yield Catalyst-Free Solutions of Parahydrogen-Hyperpolarized [1-13C]succinate
Chemical Communications. 2023. V.59. N62. P.9509-9512. DOI: 10.1039/d3cc01803b WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Apr 13, 2023
Accepted:	Jun 20, 2023
Published online:	Jul 14, 2023
Published print:	Aug 11, 2023

Web of science:	WOS:001028025900001
Scopus:	2-s2.0-85166209934
Elibrary:	54368729
Chemical Abstracts:	2023:1490471
PMID:	37450281
OpenAlex:	W4384347300

DB	Citing
Scopus	2
Web of science	1
OpenAlex	3
Elibrary	1