Ligand-free Ullmann-type Arylation of Oxazolidinones by Diaryliodonium Salts | Sciact - CRIS-система Института катализа

Ligand-free Ullmann-type Arylation of Oxazolidinones by Diaryliodonium Salts Научная публикация

Журнал

Organic and Biomolecular Chemistry
ISSN: 1477-0520 , E-ISSN: 1477-0539

Вых. Данные

Год: 2023, Том: 21, Номер: 9, Страницы: 1952-1957 Страниц : 6 DOI: 10.1039/d2ob02122f

Авторы

Podrezova Ekaterina V. ¹ , Okhina Alina A. ^2,3 , Rogachev Artem D. ^2,3 , Baykov Sergey ^4,1 , Kirschning Andreas ⁵ , Yusubov Mekhman ¹ , Soldatova Natalia S. ¹ , Postnikov Pavel S ^6,1

Организации

1	Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634034, Russia
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, acad. Lavrentiev ave., 9, Novosibirsk 630090, Russia
3	Novosibirsk State University, Pirogov str., 2, Novosibirsk 630090, Russia
4	Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia
5	Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover, Germany
6	Department of Solid State Engineering, Institute of Chemical Technology, Prague 16628, Czech Republic

The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds. In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts. The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted. The efficiency of the method was demonstrated for a wide range of diaryliodonium salts – symmetric and unsymmetric as well as ortho-substituted derivatives. The developed approach will provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties.

Podrezova E.V. , Okhina A.A. , Rogachev A.D. , Baykov S. , Kirschning A. , Yusubov M. , Soldatova N.S. , Postnikov P.S.
Ligand-free Ullmann-type Arylation of Oxazolidinones by Diaryliodonium Salts
Organic and Biomolecular Chemistry. 2023. V.21. N9. P.1952-1957. DOI: 10.1039/d2ob02122f WOS Scopus CAPlusCA PMID OpenAlex

Поступила в редакцию:	22 нояб. 2022 г.
Принята к публикации:	6 февр. 2023 г.
Опубликована online:	6 февр. 2023 г.
Опубликована в печати:	7 мар. 2023 г.

Web of science:	WOS:000931652900001
Scopus:	2-s2.0-85148677194
Chemical Abstracts:	2023:302508
Chemical Abstracts (print):	182:48133
PMID (PubMed):	36757159
OpenAlex:	W4319316443

БД	Цитирований
OpenAlex	5
Web of science	6
Scopus	5