Aliphatic C-H Azidation by Mn Based Mimics of α-Ketoglutarate Dependent Enzymes Научная публикация
Журнал |
Journal of Catalysis
ISSN: 0021-9517 , E-ISSN: 1090-2694 |
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Вых. Данные | Год: 2024, Том: 429, Номер статьи : 115275, Страниц : 6 DOI: 10.1016/j.jcat.2023.115275 | ||||||||
Ключевые слова | Asymmetric catalysis; Azidation; C-H activation; Enzyme models; Hydrogen peroxide; Manganese | ||||||||
Авторы |
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Организации |
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Реферат:
α-Ketoglutarate dependent nonheme halogenases catalyze regioselective functionalization of aliphatic C-H bonds via H abstraction by the ferryl site of the [X−FeIV=O] intermediate, followed by radical rebound to an adjacent halogen ligand X at the same Fe center. Herein we report biomimetic nonheme Mn complexes, possessing two labile cis-α coordination sites and capable of catalyzing the enantioselective azidation of C(sp3)−H groups. Proper ligand environment of the active sites imposes steric constraints on HO−Mn rebound, thus accounting for preferential C-radical rebound to the adjacent N3−Mn ligand. Such mechanism of selectivity control is analogous to that operating in the prototypical α-ketoglutarate-dependent nonheme iron halogenases.
Библиографическая ссылка:
Ottenbacher R.V.
, Lubov D.P.
, Samsonenko D.G.
, Nefedov A.A.
, Bryliakov K.P.
Aliphatic C-H Azidation by Mn Based Mimics of α-Ketoglutarate Dependent Enzymes
Journal of Catalysis. 2024. V.429. 115275 :1-6. DOI: 10.1016/j.jcat.2023.115275 WOS Scopus CAPlusCA OpenAlex
Aliphatic C-H Azidation by Mn Based Mimics of α-Ketoglutarate Dependent Enzymes
Journal of Catalysis. 2024. V.429. 115275 :1-6. DOI: 10.1016/j.jcat.2023.115275 WOS Scopus CAPlusCA OpenAlex
Даты:
Поступила в редакцию: | 21 нояб. 2023 г. |
Принята к публикации: | 21 дек. 2023 г. |
Опубликована online: | 27 дек. 2023 г. |
Опубликована в печати: | 1 янв. 2024 г. |
Идентификаторы БД:
Web of science: | WOS:001166120900001 |
Scopus: | 2-s2.0-85181140936 |
Chemical Abstracts: | 2024:47014 |
Chemical Abstracts (print): | 185:313206 |
OpenAlex: | W4390277711 |