Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus | Sciact - CRIS-system of Boreskov Institute of Catalysis

Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus Full article

Journal

Proceedings of The Royal Society B - Biological Sciences
ISSN: 0962-8452 , E-ISSN: 1471-2954

Output data

Year: 2014, Volume: 281, Number: 1792, Pages: 20140919 Pages count : 6 DOI: 10.1098/rspb.2014.0919

Tags

Adaptation to dust, Ellobius, Mus, Nanoparticles, Nasal aerodynamics, Subterranean rodents

Authors

Moshkin M.P. ^1,7,8 , Petrovski D.V. ¹ , Akulov A.E. ¹ , Romashchenko A.V. ^1,5 , Gerlinskaya L.A. ¹ , Ganimedov V.L. ² , Muchnaya M.I. ² , Sadovsky A.S. ² , Koptyug I.V. ³ , Savelov A.A. ³ , Troitsky S.Yu. ⁴ , Moshkin Y.M. ⁶ , Bukhtiyarov V.I. ⁴ , Kolchanov N.A. ^1,7 , Sagdeev R.Z. ³ , Fomin V.M. ²

Affiliations

1	Institute of Cytology and Genetics
2	Khristianovich Institute of Theoretical and Applied Mechanics
3	International Tomographic Center
4	Boreskov Institute of Catalysis
5	Design Technological Institute of Digital Techniques, Siberian Branch of RAS, Novosibirsk 630090, Russia
6	Department of Biochemistry, Erasmus Medical Center, Dr. Molewaterplein 50, Rotterdam 3015GE, The Netherlands
7	Department of Physiology, Novosibirsk State University, Novosibirsk 630090, Russia
8	Department of Zoology and Animal Ecology, Tomsk State University, Tomsk 634050, Russia

Funding (6)

1	Siberian Branch of the Russian Academy of Sciences	57
2	Siberian Branch of the Russian Academy of Sciences	60
3	Siberian Branch of the Russian Academy of Sciences	61
4	Siberian Branch of the Russian Academy of Sciences	108
5	Siberian Branch of the Russian Academy of Sciences	122
6	Russian Science Foundation	14-14-00221

Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent Mus musculus (mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl2 aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl2 solution and hydrated nanoparticles of manganese oxide MnO · (H2O)x revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles.

Moshkin M.P. , Petrovski D.V. , Akulov A.E. , Romashchenko A.V. , Gerlinskaya L.A. , Ganimedov V.L. , Muchnaya M.I. , Sadovsky A.S. , Koptyug I.V. , Savelov A.A. , Troitsky S.Y. , Moshkin Y.M. , Bukhtiyarov V.I. , Kolchanov N.A. , Sagdeev R.Z. , Fomin V.M.
Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus

Proceedings of The Royal Society B - Biological Sciences. 2014. V.281. N1792. P.20140919. DOI: 10.1098/rspb.2014.0919 WOS Scopus РИНЦ РИНЦ PMID OpenAlex

Full text from publisher

Submitted:	Apr 17, 2014
Accepted:	Jul 23, 2014
Published online:	Aug 20, 2014
Published print:	Oct 7, 2014

Web of science:	WOS:000341095900008
Scopus:	2-s2.0-85006257538
Elibrary:	23983828 \| 41767099
PMID:	25143031
OpenAlex:	W1972091988

DB	Citing
Web of science	9
Scopus	10
Elibrary	6 11
OpenAlex	12