Diffusion-Limited Release of Molecules from Nanocarriers with Appreciable Energetic Heterogeneity Full article
| Journal |
The Journal of Physical Chemistry C
ISSN: 1932-7447 , E-ISSN: 1932-7455 |
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| Output data | Year: 2024, Volume: 128, Number: 3, Pages: 1216–1221 Pages count : 6 DOI: 10.1021/acs.jpcc.3c08017 | ||
| Tags | Binding energy; Binding sites; Controlled drug delivery; Diffusion; Targeted drug delivery; Weibull distribution | ||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Ministry of Science and Higher Education of the Russian Federation | ГЗ-2024-2028 |
Abstract:
Carriers with a size of ∼100–200 nm are now used in various applications related, e.g., to drug and vaccine delivery. Such carriers are structurally heterogeneous, and this results in appreciable energetic heterogeneity for the diffusion of cargo molecules. In particular, the diffusion coefficient becomes dependent on the concentration of molecules, and this dependence is related to the distribution of attachment sites over binding energy. Taking this distribution into account and integrating the corresponding diffusion equation, the author shows that in this case, the release kinetics are logarithmic. Such kinetics can be fitted by employing the Weibull expression with the exponent in the range of 0.35 to 0.45. This range is relevant in the context of recent experiments with nanocarriers.
Cite:
Zhdanov V.P.
Diffusion-Limited Release of Molecules from Nanocarriers with Appreciable Energetic Heterogeneity
The Journal of Physical Chemistry C. 2024. V.128. N3. P.1216–1221. DOI: 10.1021/acs.jpcc.3c08017 WOS Scopus РИНЦ AN OpenAlex
Diffusion-Limited Release of Molecules from Nanocarriers with Appreciable Energetic Heterogeneity
The Journal of Physical Chemistry C. 2024. V.128. N3. P.1216–1221. DOI: 10.1021/acs.jpcc.3c08017 WOS Scopus РИНЦ AN OpenAlex
Dates:
| Submitted: | Dec 7, 2023 |
| Accepted: | Dec 18, 2023 |
| Published online: | Jan 9, 2024 |
| Published print: | Jan 25, 2024 |
Identifiers:
| Web of science: | WOS:001151536400001 |
| Scopus: | 2-s2.0-85182568264 |
| Elibrary: | 65835955 |
| Chemical Abstracts: | 2024:60312 |
| OpenAlex: | W4390729270 |