Pre-Pandemic Cross-Reactive Immunity Against SARS-CoV-2 among Siberian Populations | Sciact - CRIS-system of Boreskov Institute of Catalysis

Pre-Pandemic Cross-Reactive Immunity Against SARS-CoV-2 among Siberian Populations Full article

Journal

Antibodies
ISSN: 2073-4468

Output data

Year: 2023, Volume: 12, Number: 4, Article number : 82, Pages count : 12 DOI: 10.3390/antib12040082

Tags

SARS-CoV-2; antibodies; IgG; coronavirus; pre-existing immunity

Authors

Shaprova Olga N. ¹ , Shanshin Daniil V. ^2,1 , Kolosova Evgeniia A. ^2,1 , Borisevich Sophia S. ^3,4 , Soroka Artem A. ⁴ , Merkuleva Iuliia A. ¹ , Nikitin Artem O. ¹ , Volosnikova Ekaterina A. ¹ , Ushkalenko Nikita D. ¹ , Zaykovskaya Anna V. ¹ , Pyankov Oleg V. ¹ , Elchaninova Svetlana A. ⁵ , Shcherbakov Dmitry N. ^2,1 , Ilyicheva Tatiana N. ¹

Affiliations

1	State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia
2	Russian-American Anti-Cancer Center, Altai State University, 656049 Barnaul, Russia
3	Laboratory of Chemical Physics, Ufa Institute of Chemistry Ufa Federal Research Center, 450078 Ufa, Russia
4	Institute of Intelligent Cybernetic Systems, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409 Moscow, Russia
5	Department of Biochemistry and Clinical Laboratory Diagnostics, Altai State Medical University, 656038 Barnaul, Russia

In December 2019, a new coronavirus, SARS-CoV-2, was found to in Wuhan, China. Cases of infection were subsequently detected in other countries in a short period of time, resulting in the declaration of the COVID-19 pandemic by the World Health Organization (WHO) on 11 March 2020. Questions about the impact of herd immunity of pre-existing immune reactivity to SARS-CoV-2 on COVID-19 severity, associated with the immunity to seasonal manifestation, are still to be resolved and may be useful for understanding some processes that precede the emergence of a pandemic virus. Perhaps this will contribute to understanding some of the processes that precede the emergence of a pandemic virus. We assessed the specificity and virus-neutralizing capacity of antibodies reacting with the nucleocapsid and spike proteins of SARS-CoV-2 in a set of serum samples collected in October and November 2019, before the first COVID-19 cases were documented in this region. Blood serum samples from 799 residents of several regions of Siberia, Russia, (the Altai Territory, Irkutsk, Kemerovo and Novosibirsk regions, the Republic of Altai, Buryatia, and Khakassia) were analyzed. Sera of non-infected donors were collected within a study of seasonal influenza in the Russian Federation. The sample collection sites were located near the flyways and breeding grounds of wild waterfowl. The performance of enzyme-linked immunosorbent assay (ELISA) for the collected sera included the usage of recombinant SARS-CoV-2 protein antigens: full-length nucleocapsid protein (CoVN), receptor binding domain (RBD) of S-protein and infection fragment of the S protein (S5-6). There were 183 (22.9%) sera reactive to the S5-6, 270 (33.8%) sera corresponding to the full-length N protein and 128 (16.2%) sera simultaneously reactive to both these proteins. Only 5 out of 799 sera had IgG antibodies reactive to the RBD. None of the sera exhibited neutralizing activity against the nCoV/Victoria/1/2020 SARS-CoV-2 strain in Vero E6 cell culture. The data obtained in this study suggest that some of the population of the analyzed regions of Russia had cross-reactive humoral immunity against SARS-CoV-2 before the COVID-19 pandemic started. Moreover, among individuals from relatively isolated regions, there were significantly fewer reliably cross-reactive sera. The possible significance of these data and impact of cross-immunity to SARS-CoV-2 on the prevalence and mortality of COVID-19 needs further assessment.

Shaprova O.N. , Shanshin D.V. , Kolosova E.A. , Borisevich S.S. , Soroka A.A. , Merkuleva I.A. , Nikitin A.O. , Volosnikova E.A. , Ushkalenko N.D. , Zaykovskaya A.V. , Pyankov O.V. , Elchaninova S.A. , Shcherbakov D.N. , Ilyicheva T.N.
Pre-Pandemic Cross-Reactive Immunity Against SARS-CoV-2 among Siberian Populations
Antibodies. 2023. V.12. N4. 82 :1-12. DOI: 10.3390/antib12040082 WOS Scopus AN PMID OpenAlex

Submitted:	Sep 28, 2023
Accepted:	Dec 1, 2023
Published print:	Dec 9, 2023
Published online:	Dec 9, 2023

Web of science:	WOS:001136107300001
Scopus:	2-s2.0-85180547665
Chemical Abstracts:	2024:135587
PMID:	38131804
OpenAlex:	W4389537604

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