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New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins Научная публикация

Журнал Molecules
ISSN: 1420-3049
Вых. Данные Год: 2023, Том: 28, Номер: 6, Номер статьи : 2673, Страниц : 19 DOI: 10.3390/molecules28062673
Ключевые слова coumarin; terpene; antiviral activity; cytotoxicity; respiratory syncytial virus; molecular modeling; F protein
Авторы Khomenko Tatyana M. 1 , Shtro Anna A. 2 , Galochkina Anastasia V. 2 , Nikolaeva Yulia V. 2 , Garshinina Anzhelika V. 2 , Borisevich Sophia S. 3,4 , Korchagina Dina V. 1 , Volcho Konstantin P. 1 , Salakhutdinov Nariman F. 1
Организации
1 Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia
2 Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, 197376 Saint-Petersburg, Russia
3 Laboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., 450054 Ufa, Russia
4 Institute of Cyber Intelligence Systems, National Research Nuclear University MEPhI, 115409 Moscow, Russia

Реферат: Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children under 3 years of age and elderly people over 65 years of age, often causing serious problems, even death. At present, there are no vaccines and specific chemotherapeutic agents for the treatment of this disease, so the search for low-molecular weight compounds to combat RSV is a challenge. In this work, we have shown, for the first time, that monoterpene-substituted arylcoumarins are efficient RSV replication inhibitors at low micromolar concentrations. The most active compound has a selectivity index of about 200 and acts most effectively at the early stages of infection. The F protein of RSV is a potential target for these compounds, which is also confirmed by molecular docking and molecular dynamics simulation data.
Библиографическая ссылка: Khomenko T.M. , Shtro A.A. , Galochkina A.V. , Nikolaeva Y.V. , Garshinina A.V. , Borisevich S.S. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins
Molecules. 2023. V.28. N6. 2673 :1-19. DOI: 10.3390/molecules28062673 WOS Scopus CAPlus PMID OpenAlex
Даты:
Поступила в редакцию: 13 янв. 2023 г.
Принята к публикации: 12 мар. 2023 г.
Опубликована в печати: 15 мар. 2023 г.
Опубликована online: 15 мар. 2023 г.
Идентификаторы БД:
Web of science: WOS:000957752300001
Scopus: 2-s2.0-85151114244
Chemical Abstracts: 2023:683323
PMID (PubMed): 36985645
OpenAlex: W4327605921
Цитирование в БД:
БД Цитирований
OpenAlex 10
Web of science 9
Scopus 10
Альметрики: