The Effectiveness of Using a Molded Sorbent: Modified Polyvinylpyrrolidone for the Combined Treatment of Chronic Endometritis | Sciact - CRIS-система Института катализа

The Effectiveness of Using a Molded Sorbent: Modified Polyvinylpyrrolidone for the Combined Treatment of Chronic Endometritis Научная публикация

Журнал

International Journal of Gynecology & Obstetrics
ISSN: 0020-7292 , E-ISSN: 1879-3479

Вых. Данные

Год: 2021, Том: 154, Номер: 2, Страницы: 277-284 Страниц : 8 DOI: 10.1002/ijgo.13609

Ключевые слова

antibiotic therapy; chronic endometritis; cytokines; microbiology; molded sorbent— modified polyvinylpyrrolidone

Авторы

Barinov Sergey V. ¹ , Tirskaya Yuliya I. ¹ , Borisova Anna V. ² , Pyanova Lidiya G. ³ , Gian Carlo Di G.C. ⁴

Организации

1	Department of Gynecology and Obstetrics No. 2, Federal State Funded Educational Institution for Higher Education Omsk State Medical University, Ministry of Public Health, Russian Federation, Omsk, Russia
2	Peoples Friendship University of Russia (RUDN, Moscow, Russia
3	Laboratory of Synthesis of Functional Carbon Materials, Institute of Hydrocarbons Processing of the Siberian Branch of the Russian Academy of Sciences, Omsk, Russia
4	Department of Obstetrics and Gynecology and Centre for Reproductive and Perinatal Medicine, University of Perugia, Perugia, Italy

Objective To improve the management of patients with chronic endometritis (CE) by using a molded sorbent-modified by polyvinylpyrrolidone (FSMP). Methods This prospective study included 70 patients with CE divided into two groups: group 1 (n = 23) received traditional antibiotic therapy (from days 3 to 10 of the menstrual cycle); group 2 (n = 47), received antibiotics and FSMP was inserted from days 5 to 10. Results At the end of therapy, group 1 had massive growth of pathogenic microflora in 21.7%, moderate growth in 69.6%, and no growth in 8.7% of cases. In group 2, after combined therapy, massive growth was observed in 4.3%, moderate growth in 44.7%, and no growth in 51.0%. In group 2 after 5 days, serum levels of interleukin-1 beta (IL-1 beta) were 1.9 times, of IL-6 were 7.0 times, and of IL-8 and IL-1 receptor antagonist were 1.3 times lower than in group 1. In uterine cavity aspirates, IL-1 beta decreased around 4.8 times, IL-6 by 11.8 times, IL-8 by 3.2 times, tumor necrosis factor-alpha by 3.9 times, and IL-1 receptor antagonist by 2.1 times in comparison to group 1. Conclusion Combined therapy of FSMP with antibiotics is more effective in treating CE, because it contributes to the almost complete elimination of pathogens and toxins from the uterine cavity, blocking the local pro-inflammatory cascade.

Barinov S.V. , Tirskaya Y.I. , Borisova A.V. , Pyanova L.G. , Gian Carlo Di G.C.
The Effectiveness of Using a Molded Sorbent: Modified Polyvinylpyrrolidone for the Combined Treatment of Chronic Endometritis
International Journal of Gynecology & Obstetrics. 2021. V.154. N2. P.277-284. DOI: 10.1002/ijgo.13609 WOS Scopus РИНЦ CAPlusCA PMID OpenAlex

Опубликована online:	11 февр. 2021 г.
Опубликована в печати:	1 авг. 2021 г.

Web of science:	WOS:000616813500001
Scopus:	2-s2.0-85101050145
РИНЦ:	46535033
Chemical Abstracts:	2021:1845359
Chemical Abstracts (print):	176:384809
PMID (PubMed):	33471361
OpenAlex:	W3125054916

БД	Цитирований
Web of science	1
Scopus	1
OpenAlex	1