Applicability of Modified Carbon Sorbent for Removing Potentially Toxic Biologically Active Molecules of Aromatic Structure from Blood Plasma
Full article
| Journal |
The International Journal of Artificial Organs
ISSN: 0391-3988
, E-ISSN: 1724-6040
|
| Output data |
Year: 2021,
Volume: 44,
Number: 12,
Pages: 930-937
Pages count
: 8
DOI:
10.1177/03913988211018478
|
| Tags |
Microbial metabolites, gas chromatography-mass spectrometry, carbon sorbents, sepsis, phenyl-containing acids, 3-phenylpropionic acid, 3-phenyllactic acid, 3-(4-hydroxyphenyl)lactic acid, 2-(4-hydroxyphenyl)acetic acid |
| Authors |
Getsina Maria
1
,
P’yanova Lidia
2
,
Kornienko Natalia
2
,
Lavrenov Alexander
2
,
Ershov Аnton
1
,
Beloborodova Natalia
1
|
| Affiliations |
| 1 |
Laboratory of Human Metabolism in Critical States, Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation
|
| 2 |
Center of New Chemical Technologies of the Federal Research Center Boreskov Institute of Catalysis of Siberian Branch of the Russian Academy of Sciences, Omsk, Russian Federation
|
|
Funding (2)
|
1
|
Ministry of Science and Higher Education of the Russian Federation
|
0364-2019-0005 ( V.45.2.8)
|
|
2
|
Ministry of Science and Higher Education of the Russian Federation
|
075-00858-19-00 (АААА-А19-119032090046-9)
|
The modification of the mesoporous carbon sorbent with 3-phenylpropanoic acid was carried out in order to create preparations of complex, prolonged action, exhibiting detoxifying, antibacterial, and antifungal properties due to the applied modifier, which is capable of migrating into the solution and exhibiting its own biospecific properties. A techniquewas developed for fixing 3-phenylpropionic acid (PhPA) on a carbon support by its adsorption from solution. Three types of sorbents with various content of the modifier (PhPA) and the sorbent without modifier were studied. The sorption activity of new sorbents was studied using liquid-liquid extraction and gas chromatography-mass spectrometry methods on model experiments with plasma and aqueous additives of hydroxylated phenyl-containing acids (PhCAs) in various concentrations. The specific surface area was significantly changed for sorbent, modified with 1 × 10−3 mol/L of PhPA solution, and was 25% less than the area of unmodified sorbent. Potentially toxic biologically active hydroxylated PhCAs were used to create model solutions. The degrees of sorption of these compounds were close to 100%, except phenyllactic acid (over 80%). The sorbent without modifier and two sorbents with the lowest content of the modifier are considered to be more effective for the purification of the plasma from the hydroxylated PhCAs than the sorbent with the highest concentration of the modifier. Simultaneous adsorption of toxic metabolites from the bloodstream and desorption of beneficial ones can be used for a more subtle correction of the patient’s condition.