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Immunization of Male BALB/c and C57BL/6 Mice Alters the Composition of Their Urine and the Response of Females to Its Odor Научная публикация

Журнал Journal of Evolutionary Biochemistry and Physiology
ISSN: 0022-0930
Вых. Данные Год: 2024, Том: 60, Номер: 4, Страницы: 1336-1346 Страниц : 11 DOI: 10.1134/s0022093024040070
Ключевые слова immunization of mice, mating preference, urinary odor, olfactory test, nonanal, benzothiazole, 2-sec-butyl-4,5-dihydro-thiazole, SBT
Авторы Khotskina A.S. 1 , Patrushev Yu.V. 2 , Yusupova D.I. 1 , Gerlinskaya L.A. 1 , Petrovskii D.V. 1 , Moshkin M.P. 1 , Zavjalov E.L. 1
Организации
1 Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2 Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia

Информация о финансировании (2)

1 Министерство науки и высшего образования Российской Федерации (с 15 мая 2018) FWNR-2022-0004
2 Российский научный фонд 23-14-00179 (123062800023-7)

Реферат: Odors play a key role in animal communication and mate choice. Male urinary odor becomes less attractive to mature females when males get infected or have their immune system activated. The development of the immune response at early stages is related to the production of both pro- and anti-inflammatory cytokines. To explore the chemical basis of the observed differences and analyze the effects of female interactions with the urinary odor of antigen-stimulated males, the males of inbred BALB/c (Th1) and C57BL/6 (Th2) mice were immunized with keyhole limpet hemocyanin (KLH). The odor of male urine collected 3 days after immunization proved to be less attractive to females of both strains compared to the odor of control males. Herewith, BALB/c females sniffed the urine of immunized males less frequently, while C57BL/6 females demonstrated a shorter duration of grooming in olfactory tests with urine of immunized males. The altered response of females to the odor of male urine collected on day 3 after KLH immunization matched antigen-induced modulation of relative levels of volatile organic compounds detected in urine samples by gas chromatography/mass spectroscopy (GC-MS). Males of both strains, after KLH immunization, exhibited an increase in the content of nonanal, benzothiazole, 2-sec-butyl-4,5-dihydrothiazole, and [1,4,5]-oxadithiepane. At the same time, no compounds were found, whose content changed multidirectionally in the urine of males after immunization in a strain-dependent manner.
Библиографическая ссылка: Khotskina A.S. , Patrushev Y.V. , Yusupova D.I. , Gerlinskaya L.A. , Petrovskii D.V. , Moshkin M.P. , Zavjalov E.L.
Immunization of Male BALB/c and C57BL/6 Mice Alters the Composition of Their Urine and the Response of Females to Its Odor
Journal of Evolutionary Biochemistry and Physiology. 2024. V.60. N4. P.1336-1346. DOI: 10.1134/s0022093024040070 WOS РИНЦ OpenAlex
Оригинальная: Хоцкина А.С. , Патрушев Ю.В. , Юсупова Д.И. , Герлинская Л.А. , Петровский Д.В. , Мошкин М.П. , Завьялов Е.Л.
Иммунизация самцов мышей BALB/c и C57BL/6 изменяет состав их мочи и реакцию самок на ее запах
Журнал эволюционной биохимии и физиологии. 2024. Т.60. №4. С.411–420. DOI: 10.31857/s0044452924040089 РИНЦ OpenAlex
Даты:
Поступила в редакцию: 9 апр. 2024 г.
Принята к публикации: 4 июн. 2024 г.
Опубликована в печати: 1 июл. 2024 г.
Опубликована online: 29 авг. 2024 г.
Идентификаторы БД:
Web of science: WOS:001303635800031
РИНЦ: 69094800
OpenAlex: W4401998821
Цитирование в БД: Пока нет цитирований
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