Assessment of OTR Measurement Techniques in the Bubble Environment of an Industrial Fermenter | Sciact - CRIS-system of Boreskov Institute of Catalysis

Assessment of OTR Measurement Techniques in the Bubble Environment of an Industrial Fermenter Full article

Journal

European Physical Journal: Special Topics
ISSN: 1951-6355 , E-ISSN: 1951-6401

Output data

Year: 2024, Volume: 233, Pages: 3519–3534 Pages count : 16 DOI: 10.1140/epjs/s11734-024-01378-x

Tags

LIQUID MASS-TRANSFER; OXYGEN-TRANSFER; TRANSFER COEFFICIENT; TRANSFER ENHANCEMENT; KLA MEASUREMENT; TRANSFER RATES; SCALE-UP; OXIDATION; BIOREACTORS; ABSORPTION

Authors

Mikushin Pavel ^1,2 , Starodumov Ilya ¹ , Shuvaev Alexander ³ , Lezhnin Sergey ¹ , Makhaeva Ksenia ¹ , Chernushkin Dmitrii ⁴ , Zagoruiko Andrey ⁵ , Minakov Denis ⁶ , Nizovtseva Irina ^1,7

Affiliations

1	Laboratory of Multiphase Physical and Biological Media Modeling, Ural Federal University, Ekaterinburg, Russia
2	Moscow Institute of Physics and Technology, Moscow, Russia
3	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
4	NPO Biosintez Ltd., Moscow, Russia
5	Boreskov Institute of Catalysis, Novosibirsk, Russia
6	Altai State University, Barnaul, Russia
7	Otto Schott Institute of Materials Research, Friedrich Schiller University, Jena, Germany

Funding (1)

Russian Science Foundation

24-11-00351 (124052700086-3)

A comprehensive assessment of oxygen transfer rate (OTR) measurement techniques in the bubble environment of large-scale industrial fermenters is presented. Specifically, we focus on the sodium sulfite and hydrogen peroxide methods, two of the most commonly used approaches for measuring OTR in high oxygen-demand systems, and compare them with the nitrogen degassing method. A theoretical review of these methods is conducted and supplemented with experimental data collected from a 5-l stirred-tank fermenter. Through this comparative analysis, the key differences between the methods are highlighted, including the enhancement factor effect, their applicability to industrial bioreactors with high volumetric mass transfer coefficients (kLa), and the challenges associated with scaling these techniques to industrial systems. Results underscore the critical role of OTR in determining mass transfer efficiency in aerobic bioreactors, while also outlining the relationship of OTR to biochemical reactions in the environment.

Mikushin P. , Starodumov I. , Shuvaev A. , Lezhnin S. , Makhaeva K. , Chernushkin D. , Zagoruiko A. , Minakov D. , Nizovtseva I.
Assessment of OTR Measurement Techniques in the Bubble Environment of an Industrial Fermenter
European Physical Journal: Special Topics. 2024. V.233. P.3519–3534. DOI: 10.1140/epjs/s11734-024-01378-x WOS Scopus РИНЦ OpenAlex

Submitted:	Sep 2, 2024
Accepted:	Oct 17, 2024
Published online:	Nov 14, 2024
Published print:	Dec 1, 2024

Web of science:	WOS:001354848900001
Scopus:	2-s2.0-85208980846
Elibrary:	78949390
OpenAlex:	W4404345970

DB	Citing
Scopus	1
Web of science	1
OpenAlex	1