The Effect of Various Surface Functionalizations of Core–Shell Nanoactuators on Magnetoelectrically Driven Cell Growth | Sciact - CRIS-система Института катализа

The Effect of Various Surface Functionalizations of Core–Shell Nanoactuators on Magnetoelectrically Driven Cell Growth Научная публикация

Журнал

ACS Applied Materials and Interfaces
ISSN: 1944-8244 , E-ISSN: 1944-8252

Вых. Данные

Год: 2025, DOI: 10.1021/acsami.4c21337

Ключевые слова

magnetoelectrics, magnetic materials, core−shell nanoparticles, surface functionalization, neuronal stimulation, cancer treatment, noninvasive electrostimulation, biomodal cell growth

Авторы

Chernozem Polina V. ¹ , Romashchenko Alexander V. ^1,2,3,4 , Solovieva Olga I. ² , Ibraeva Azhar Zh. ^1,2 , Nosov Georgy ³ , Koptsev Danila A. ¹ , Lisitsyn Sergey A. ^3,4 , Surmeneva Maria A. ¹ , Wagner Dmitry V. ⁵ , Gerasimov Evgeny Yu. ⁶ , Kazantsev Sergey O. ⁷ , Lozhkomoev Aleksandr S. ⁷ , Sukhorukov Gleb B. ⁴ , Surmenev Roman A. ¹ , Chernozem Roman V. ¹

Организации

1	National Research Tomsk Polytechnic University, Tomsk 634050, Russia
2	The Federal Research Center Institute of Cytology and Genetic, SB RAS, Novosibirsk 630090, Russia
3	Life Improvement by Future Technology Center LLC (LIFT), Moscow 121205, Russia
4	Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Moscow 121205, Russia
5	National Research Tomsk State University, Tomsk 634050, Russia
6	Boreskov Institute of Catalysis, Novosibirsk 630090, Russia
7	Institute of Strength Physics and Materials Science, SB RAS, Tomsk 634055, Russia

Информация о финансировании (1)

Российский научный фонд

23-23-00511 (123012000053-7)

Magnetoelectric (ME) nanoparticles (NPs) exhibit strong coupling between magnetic and electric properties, enabling wireless control of biological processes through electromagnetic stimulation, which paves the way for diverse biomedical applications. However, the surface functionalization of ME NPs and its impact on their structure, physical properties, and biological response remain largely unexplored. In this study, biocompatible citric acid (CA) and pectin (PEC) were employed to functionalize quasi-spherical ME core–shell NPs comprising a magnetic spinel MnFe2O4 core (∼23 nm) and a ferroelectric perovskite Ba0.85Ca0.15Zr0.1Ti0.9O3 (BCZT) shell (∼5 nm), synthesized using microwave-assisted hydrothermal processing. The surface functionalization led to the formation of covalent bonds between CA and metal ions of NPs via chelation. The surface functionalization with PEC increased ζ-potential values of ME NPs up to −46.2 ± 0.6 mV compared to CA (25.3 ± 1.0 mV). Both MFO@BCZT NPs with CA and PEC exhibited low coercivity values (69 ± 5 and 29 ± 2 Oe, respectively) with a pronounced specific saturation magnetization (6.1 ± 0.2 and 5.2 ± 0.2 emu/g, respectively). No effect of the BCZT shell with subsequent CA (746 ± 22 Oe) and PEC (754 ± 23 Oe) surface functionalizations on the anisotropy field of ME NPs was observed compared to the pristine MFO cores (754 ± 23 Oe). Both CA-/PEC-functionalized MFO@BCZT NPs exhibited ferroelectric behavior with robust piezoresponse (9.95 ± 1.36 and 10.24 ± 2.03 pm/V, respectively) and high ME response (81 × 104 and 80 × 104 mV·cm–1·Oe–1, respectively), comparable to the most frequently studied Co-based analogs. In vitro assays demonstrated the ability of the developed ME NPs to control calcium flux, which enables bidirectional regulation of cell proliferation. This work advances the development of efficient and biocompatible ME NPs with promising applications in the noninvasive and targeted stimulation of cell behavior.

Chernozem P.V. , Romashchenko A.V. , Solovieva O.I. , Ibraeva A.Z. , Nosov G. , Koptsev D.A. , Lisitsyn S.A. , Surmeneva M.A. , Wagner D.V. , Gerasimov E.Y. , Kazantsev S.O. , Lozhkomoev A.S. , Sukhorukov G.B. , Surmenev R.A. , Chernozem R.V.
The Effect of Various Surface Functionalizations of Core–Shell Nanoactuators on Magnetoelectrically Driven Cell Growth
ACS Applied Materials and Interfaces. 2025. DOI: 10.1021/acsami.4c21337 WOS Scopus OpenAlex

Поступила в редакцию:	4 дек. 2024 г.
Принята к публикации:	18 февр. 2025 г.
Опубликована online:	20 мар. 2025 г.

Web of science:	WOS:001456009300001
Scopus:	2-s2.0-105001507499
OpenAlex:	W4409034750

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