Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation | Sciact - CRIS-system of Boreskov Institute of Catalysis

Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation Full article

Journal

ACS Applied Nano Materials
ISSN: 2574-0970

Output data

Year: 2025, Volume: 8, Number: 14, Pages: 6930–6942 Pages count : 13 DOI: 10.1021/acsanm.4c07085

Tags

magnetic nanoparticles, glioblastoma, olfactory stimulation, neuronal activity, manganese-enhanced MRI, nasal transport, neuron-to-glioma communication, targeted delivery

Authors

Sharapova Marina B. ¹ , Zuev Daniil S. ¹ , Silvanovich Elizaveta K. ¹ , Ibraeva Azhar Zh. ^1,2,3 , Morozova Ksenia N. ¹ , Kiseleva Elena V. ¹ , Chernozem Polina V. ² , Urakova Alina O. ² , Wagner Dmitry V. ⁴ , Gerasimov Evgeny Yu. ⁵ , Shevelev Oleg B. ¹ , Sukhov Boris G. ⁶ , Surmeneva Maria A. ² , Surmenev Roman A. ² , Zavjalov Evgenii L. ¹ , Chernozem Roman V. ² , Romashchenko Alexander V. ^1,2,7

Affiliations

1	Federal research center Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia
2	National Research Tomsk Polytechnic University, Tomsk 634050, Russia
3	Federal Research Center for Information and Computational Technologies, Novosibirsk 630090, Russia
4	National Research Tomsk State University, Tomsk 634050, Russia
5	Boreskov Institute of Catalysis, SB RAS, Novosibirsk 630090, Russia
6	Voevodsky Institute of Chemical Kinetics and Combustion, SB RAS, Novosibirsk 630090, Russia
7	Life Improvement by Future Technology Center LLC (LIFT), Moscow 121205, Russia

Funding (3)

1	Russian Science Foundation	24-43-00171 (123122100091-4)
2	The Ministry of Education and Science of the Russian Federation	14.621.21.0015 (RFMEFI62117X0015)
3	Ministry of Science and Higher Education of the Russian Federation	FWNR-2025-0019

Nanotechnology-based approaches are increasingly recognized in cancer biology owing to their substantial impact on various tumor cells. Nanoparticles (NPs) can serve as carriers of nanoscale drug cargos and traverse neuronal cell membranes within the nasal cavity, thereby providing an effective means to bypass the blood–brain barrier, which otherwise limits the delivery of therapeutic agents to the brain. In this study, we investigated the feasibility of axonal trans-synaptic transport of MRI-sensitive magnetic MnFe2O4 (MFO) NPs from the nasal cavity to intracranially xenotransplanted glioblastoma in SCID mice. Using T1-weighted MRI, we mapped the distribution of MFO NPs and found that they accumulated in the tumor only when the glioblastoma was in direct contact with olfactory-system structures involved in nose-to-brain transport. Additionally, inhibition of axonal transport nearly abrogated the NP delivery to the tumor. Notably, olfactory-system stimulations via odor presentation significantly enhanced the nose-to-glioblastoma transport of MFO NPs. Thus, although neuronal interactions with cancer cells have detrimental effects, these interactions may also expand opportunities for targeted drug delivery during glioblastoma treatment.

Sharapova M.B. , Zuev D.S. , Silvanovich E.K. , Ibraeva A.Z. , Morozova K.N. , Kiseleva E.V. , Chernozem P.V. , Urakova A.O. , Wagner D.V. , Gerasimov E.Y. , Shevelev O.B. , Sukhov B.G. , Surmeneva M.A. , Surmenev R.A. , Zavjalov E.L. , Chernozem R.V. , Romashchenko A.V.
Nose-to-Glioblastoma Axonal Transport of Manganese Ferrite Nanoparticles under the Influence of Olfactory Stimulation
ACS Applied Nano Materials. 2025. V.8. N14. P.6930–6942. DOI: 10.1021/acsanm.4c07085 WOS Scopus OpenAlex

Submitted:	Dec 15, 2024
Accepted:	Mar 23, 2025
Published online:	Mar 25, 2025

Web of science:	WOS:001458459600001
Scopus:	2-s2.0-105001597796
OpenAlex:	W4409077681

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