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Parahydrogen-Hyperpolarized Propane-d6 Gas Contrast Agent: T1 Relaxation Dynamics and Pilot Millimeter-Scale Ventilation MRI Full article

Journal The Journal of Physical Chemistry A
ISSN: 1089-5639 , E-ISSN: 1520-5215
Output data Year: 2025, Volume: 129, Number: 19, Pages: 4275–4287 Pages count : 13 DOI: 10.1021/acs.jpca.4c08800
Tags Angiography; Lung cancer; Pulmonary diseases; Spin polarization
Authors Ariyasingha Nuwandi M. 1 , Oladun Clementinah 1 , Samoilenko Anna 1 , Chowdhury Md Raduanul H. 1 , Nantogma Shiraz 1 , Shi Zhongjie 2 , Luo Kehuan 2 , Tan Sidhartha 2 , Salnikov Oleg G. 3 , Xhupi Alba 1 , Suleiman Majd 1 , Chekmenev Yuri A. 4 , Kovtunova Larisa M. 3,5 , Koptyug Igor V. 3 , Gelovani Juri G. 1 , Goodson Boyd M. 6 , Chekmenev Eduard Y. 1
Affiliations
1 Department of Chemistry, Integrative Biosciences (IBio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan 48202, United States
2 Department of Pediatrics, Wayne State University, Detroit, Michigan 48202, United States
3 International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk 630090, Russia
4 XeUS Technologies LTD., Nicosia 2312, Cyprus
5 Boreskov Institute of Catalysis SB RAS, 5 Acad, Lavrentiev Pr., Novosibirsk 630090, Russia
6 School of Chemical and Biomolecular Sciences, Southern Illinois University, Carbondale, Illinois 62901, United States

Funding (13)

1 United States Department of Defense W81XWH-20-1-0576
2 United States Department of Defense W81XWH-20-10578
3 National Science Foundation CHE–2404387
4 National Science Foundation CHE-2404388
5 National Heart Lung and Blood Institute R21HL168430-01A1
6 National Heart Lung and Blood Institute 1F32HL160108
7 National Institutes of Health R01NS114972
8 National Institutes of Health R01NS117146
9 National Institutes of Health R01NS130258
10 Wayne State University
11 Ministry of Science and Higher Education of the Russian Federation FWZS-2022-0002 (122040800222-3)
12 Ministry of Science and Higher Education of the Russian Federation FWUR-2024-0032
13 Ministry of Science and Higher Education of the Russian Federation 0267-2021-0004 (АААА-А21-121012290043-3)

Abstract: Hyperpolarized (HP) MRI provides enhanced signals over conventional MRI due to the increase in nuclear spin polarization by orders of magnitude compared to thermal polarization. Therefore, HP MRI can be successfully utilized toward imaging of low-density gases in void spaces, such as human lungs. Specifically, in clinical pulmonary imaging, HP MRI employs a gaseous contrast agent that fills the lungs during inhalation under physiologically relevant conditions prior to imaging. FDA-approved HP 129Xe gas can now be used as the first HP inhalable gaseous contrast agent for functional lung imaging in adults and pediatric patients above 12 years for diagnosis and monitoring responses to the treatment of many pulmonary diseases. However, despite the substantial success of HP 129Xe in research settings, the production and MRI of this novel contrast agent remain expensive and not universally available on clinical MRI scanners. An alternative approach is to deploy a proton-hyperpolarized gas that is cheap and fast to produce and can be detected on any clinical MRI scanner without any modification. Hyperpolarized propane gas has recently emerged as a potential next-generation hyperpolarized inhalable contrast agent. Here, the relaxation dynamics of two deuterated hyperpolarized propane isotopologues have been explored at clinically relevant conditions of 1 atm gas pressure and 0.35 and 1.4 T magnetic fields using pairwise addition of parahydrogen to a corresponding unsaturated precursor over the heterogeneous Rh/TiO2 catalyst. The T1 relaxation time of HP propane-d6 gas (0.91±0.03 s) at 1.4 T was found to be similar to that of HP propane gas (0.81±0.06 s) because the dominating relaxation mechanism is due to the coupling of the nuclear spins to the molecular rotation of these two propane gas isotopologues. Moreover, the effective polarization decay constant increases for HP propane-d6 to 1.35±0.05 s (and for HP propane to 1.35±0.10 s) at 0.35 T, pointing to the likely “partial” presence of the long-lived spin states (LLSS) at this clinically relevant field, corresponding to the intermediate spin–spin coupling regime of the two parahydrogen-derived hyperpolarized sites. Furthermore, the pilot feasibility of rapid lung ventilation imaging with 1 × 1 × 9 mm2 voxel-size spatial resolution using a clinical 0.35 T open MRI scanner was demonstrated by inflating HP propane-d6 gas in excised rabbit lungs, despite the reduction of the HP gas relaxation constant to 0.78 ± 0.02 s in the lungs.
Cite: Ariyasingha N.M. , Oladun C. , Samoilenko A. , Chowdhury M.R.H. , Nantogma S. , Shi Z. , Luo K. , Tan S. , Salnikov O.G. , Xhupi A. , Suleiman M. , Chekmenev Y.A. , Kovtunova L.M. , Koptyug I.V. , Gelovani J.G. , Goodson B.M. , Chekmenev E.Y.
Parahydrogen-Hyperpolarized Propane-d6 Gas Contrast Agent: T1 Relaxation Dynamics and Pilot Millimeter-Scale Ventilation MRI
The Journal of Physical Chemistry A. 2025. V.129. N19. P.4275–4287. DOI: 10.1021/acs.jpca.4c08800 WOS Scopus PMID OpenAlex
Dates:
Submitted: Dec 30, 2024
Accepted: Apr 16, 2025
Published online: May 1, 2025
Published print: May 15, 2025
Identifiers:
Web of science: WOS:001480018500001
Scopus: 2-s2.0-105004009388
PMID: 40311080
OpenAlex: W4409989008
Citing: Пока нет цитирований
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