Silver Micro- and Nanoparticles Filled Siliconefor Limb Prosthetics | Sciact - CRIS-система Института катализа

Silver Micro- and Nanoparticles Filled Siliconefor Limb Prosthetics Научная публикация

Журнал

Biomaterials Translational
ISSN: 2096-112X

Вых. Данные

Год: 2025, Номер статьи : 00073, Страниц : 10 DOI: 10.12336/bmt.24.00073

Ключевые слова

Antibacterial materials; Limb prosthetics; Medical materials; Nanomaterials; Silicone; Silver

Авторы

Eksharova Sofiya ¹ , Poletaeva Yuliya ² , Kurenkova Anna ³ , Mishchenko Denis ⁴ , Aydakov Egor ⁴ , Serdyukov Vladimir ¹

Организации

1	Biomechanics and medical engineering laboratory, Novosibirsk State University, Novosibirsk, Russia
2	Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia
3	Department of heterogeneous catalysis, Boreskov Institute of Catalysis SB RAS
4	Synchrotron Radiation Facility SKIF, Boreskov Institute of Catalysis, Kol’tsovo, Russia

The threat of bacterial growth on the skin under the prosthetic liners or sleeves is an important problem, which can cause various serious diseases up to the repeated amputation.One of the promising ways to solve this problem is to use antibacterial materials as a liner/sleeve material. Among others composite based on the silicone polymer with silver particles additive is may be a simple and effective solution, since the silicone is the main material for the prosthetic liners and sleeves and silver demonstrates pronounced antibacterial effect.However, the questions related to the optimal concentration of silver in silicone that results in maximum antibacterial efficiency without harming human skin are still open. In the present work, synthesis of metallic silver powder from a mixture of micro- and nanoparticles was performed and composite samples based on silicone polymer with different silver concentrations were fabricated. The antibacterial properties of fabricated samples were studied using the microdilution method against gram-positive spore-forming bacteria Bacillus subtilis. The cytotoxic effect of the tested samples was evaluated on healthy human fibroblast cell (NAF1nor). Moreover, the effect of adding silver micro- and nanoparticles to silicone on its extensibility and hardness was studied. The results showed that the addition of silver has a noticeable effect on the antibacterial properties of silicone polymer reaching more than 50%. Furthermore, all tested silicone-silver composites were shown to be nontoxic.The presence of silver does not significantly affect the relative elongation of the samples. However, hardness increases with higher silver concentrations. In the final phase,prototypes of the silver-filled silicone prosthetic sleeve were fabricated for utilisation by the patient at the prosthetic-orthopaedic clinic. The testing of the prototype was successfully completed by the patient, thereby demonstrating practical functionality and suitability for clinical use.

Eksharova S. , Poletaeva Y. , Kurenkova A. , Mishchenko D. , Aydakov E. , Serdyukov V.
Silver Micro- and Nanoparticles Filled Siliconefor Limb Prosthetics
Biomaterials Translational. 2025. 00073 :1-10. DOI: 10.12336/bmt.24.00073 СКИФ ID

Поступила в редакцию:	20 окт. 2024 г.
Принята к публикации:	14 февр. 2025 г.
Опубликована online:	24 апр. 2025 г.

СКИФ ID:

3855

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