Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan | Sciact - CRIS-система Института катализа

Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan Научная публикация

Журнал

Eurasian Journal of Chemistry
ISSN: 2959-0663

Вых. Данные

Год: 2025, DOI: 10.31489/2959-0663/2-25-6

Ключевые слова

Carboxyethylchitosan, biopolymer, gel phase synthesis, derivatization, Michael reaction, pH-sensitive swelling, porosity, green chemistry

Авторы

Dubovskaia Polina I. ¹ , Saeidi Arsalan ^1,2 , Pronchenko Anna A. ¹ , Drannikova Anastasiia I. ¹ , Lukoyanov Ivan A. ^1,3 , Aripova Farida K. ^1,4 , Savenko Mariia E. ¹ , Veretennikova Elizaveta A. ⁵ , Pestov Alexander V. ⁵ , Litvinova Ekaterina A. ¹ , Drannikov Aleksandr A. ¹

Организации

1	Novosibirsk State Technical University, Novosibirsk, Russia
2	Novosibirsk State University, Novosibirsk, Russia
3	Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
4	Novosibirsk State Agrarian University, Novosibirsk, Russia
5	I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia

Информация о финансировании (1)

Министерство науки и высшего образования Российской Федерации (с 15 мая 2018)

Приоритет 2030

The applicability of native chitosan-based compositions is constrained by their limited solubility in weakly alkaline and neutral media, a consequence of inherent structural features. To overcome this limitation, carboxyalkylation strategies such as the gel-phase Michael synthesis of N-carboxyethylchitosan (N-CEC) were investigated with a focus on optimizing reaction parameters to enhance yield and tailor biopolymer properties. Structural confirmation of the synthesized polymers was performed via FT-IR and SEM, while elemental analysis quantified the degree of substitution (DS), which correlated with temperature in the following way: DS = 0.96–1.10 at 50 °C, 1.07–1.12 at 60 °C and 1.16–1.32 at 70 °C. Porosity measurements indicated pore sizes ranging from 50 to 200 µm in all samples; however, total porosity varied significantly, reaching a maximum of 15 % at 70 °C and decreasing to 4–10 % at lower temperatures. N-CEC exhibited pH‑dependent swelling, with minimal expansion (100–150 %) at low pH and a 2–3-fold increase at pH > 7, which was attributed to COO⁻ group formation. These findings position N-CEC as a promising material for pH-responsive applications.

Dubovskaia P.I. , Saeidi A. , Pronchenko A.A. , Drannikova A.I. , Lukoyanov I.A. , Aripova F.K. , Savenko M.E. , Veretennikova E.A. , Pestov A.V. , Litvinova E.A. , Drannikov A.A.
Gel-Phase Synthesis and pH-Sensitive Swelling-Structure Relationships of N-Carboxyethylchitosan
Eurasian Journal of Chemistry. 2025. DOI: 10.31489/2959-0663/2-25-6 WOS OpenAlex

Поступила в редакцию:	14 мар. 2025 г.
Принята к публикации:	20 мая 2025 г.
Опубликована online:	4 июн. 2025 г.

Web of science:	WOS:001504149700001
OpenAlex:	W4411034586

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