Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies | Sciact - CRIS-система Института катализа

Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies Научная публикация

Журнал

Antibodies
ISSN: 2073-4468

Вых. Данные

Год: 2025, Том: 14, Номер: 1, Номер статьи : 22, Страниц : 24 DOI: 10.3390/antib14010022

Ключевые слова

Ebola virus disease; filoviruses; passive immunization; neutralizing antibodies; monoclonal antibodies

Авторы

Shcherbakov Dmitriy N. ¹ , Isaeva Anastasiya A. ¹ , Mustaev Egor A. ^2,3

Организации

1	State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, Koltsovo 630559, Russia
2	Department of Natural Sciences, Novosibirsk State University, Pirogova st., 2, Novosibirsk 630090, Russia
3	Synchrotron Radiation Facility—Siberian Circular Photon Source “SKlF” Boreskov Institute of Catalysis of Siberian Branch of the Russian Academy of Sciences, Nikolskiy pr-t, 1, Koltsovo 630559, Russia

Ebola virus disease (EVD) is an acute illness with a high-case fatality rate (CFR) caused by an RNA virus belonging to the Filoviridae family. Over the past 50 years, regular EVD outbreaks have been reported. The West African EVD outbreak of 2013–2016 proved to be significantly more widespread and complex than previous ones, resulting in approximately 11,000 deaths. A coordinated international effort was required to bring the outbreak under control. One of the main challenges faced by clinicians and researchers combating EVD was the absence of vaccines and preventive treatments. Only recently have efforts led to the development of effective therapeutic options. Among these, monoclonal antibody-based drugs have emerged as the most promising agents for the urgent treatment of EVD. This article aims to review the key milestones in the development of antibody-based therapies for EVD, tracing the journey from the use of convalescent serum to the creation of effective monoclonal antibody-based drugs and their combinations

Shcherbakov D.N. , Isaeva A.A. , Mustaev E.A.
Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies
Antibodies. 2025. V.14. N1. 22 :1-24. DOI: 10.3390/antib14010022 Scopus OpenAlex СКИФ ID

Поступила в редакцию:	8 дек. 2024 г.
Принята к публикации:	19 февр. 2025 г.
Опубликована online:	5 мар. 2025 г.

Scopus:	2-s2.0-105001155395
OpenAlex:	W4408218950
СКИФ ID:	3963

БД	Цитирований
Scopus	1
OpenAlex	2