Ultrasensitive Detection of Inhaled Organic Aerosol Particles by Accelerator Mass Spectrometry | Sciact - CRIS-system of Boreskov Institute of Catalysis

Ultrasensitive Detection of Inhaled Organic Aerosol Particles by Accelerator Mass Spectrometry Full article

Journal

Chemosphere
ISSN: 0045-6535 , E-ISSN: 1879-1298

Output data

Year: 2016, Volume: 159, Pages: 80-88 Pages count : 9 DOI: 10.1016/j.chemosphere.2016.05.078

Tags

Accelerator mass-spectrometry, Low-dose inhalation, Mice, Organic aerosols, Polystyrene beads, Radiocarbon

Authors

Parkhomchuk E.V. ^1,2 , Gulevich D.G. ^1,2 , Taratayko A.I. ^1,3 , Baklanov A.M. ⁴ , Selivanova A.V. ^1,5 , Trubitsyna T.A. ⁵ , Voronova I.V. ¹ , Kalinkin P.N. ^1,2 , Okunev A.G. ^1,2 , Rastigeev S.A. ^1,6 , Reznikov V.A. ^1,3 , Semeykina V.S. ^1,2 , Sashkina K.A. ^1,2 , Parkhomchuk V.V. ^1,6

Affiliations

1	Novosibirsk State University, Laboratory of Radiocarbon Methods of Analyses, 2 Pirogova st., Novosibirsk, 630090, Russia
2	Boreskov Institute of Catalysis SB RAS, 5 Lavrentieva st., Novosibirsk, 630090, Russia
3	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 9 Lavrentieva st., Novosibirsk, 630090, Russia
4	Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya st., Novosibirsk, 630090, Russia
5	JSC Tion, 20 Injenernaya str., 630090, Novosibirsk, Russia
6	Budker Institute of Nuclear Physics SB RAS, 11 Lavrentieva st., Novosibirsk 630090, Russia

Accelerator mass spectrometry (AMS) was shown to be applicable for studying the penetration of organic aerosols, inhaled by laboratory mice at ultra-low concentration ca. 103 cm−3. We synthesized polystyrene (PS) beads, composed of radiocarbon-labeled styrene, for testing them as model organic aerosols. As a source of radiocarbon we used methyl alcohol with radioactivity. Radiolabeled polystyrene beads were obtained by emulsifier-free emulsion polymerization of synthesized 14C-styrene initiated by K2S2O8 in aqueous media. Aerosol particles were produced by pneumatic spraying of diluted 14C-PS latex. Mice inhaled 14C-PS aerosol consisting of the mix of 103 225-nm particles per 1 cm3 and 5·103 25-nm particles per 1 cm3 for 30 min every day during five days. Several millions of 225-nm particles deposited in the lungs and slowly excreted from them during two weeks of postexposure. Penetration of particles matter was also observed for liver, kidneys and brain, but not for a heart.

Parkhomchuk E.V. , Gulevich D.G. , Taratayko A.I. , Baklanov A.M. , Selivanova A.V. , Trubitsyna T.A. , Voronova I.V. , Kalinkin P.N. , Okunev A.G. , Rastigeev S.A. , Reznikov V.A. , Semeykina V.S. , Sashkina K.A. , Parkhomchuk V.V.
Ultrasensitive Detection of Inhaled Organic Aerosol Particles by Accelerator Mass Spectrometry
Chemosphere. 2016. V.159. P.80-88. DOI: 10.1016/j.chemosphere.2016.05.078 WOS Scopus РИНЦ AN PMID OpenAlex

Submitted:	Mar 15, 2016
Accepted:	May 27, 2016
Published online:	Jun 6, 2016
Published print:	Sep 1, 2016

Web of science:	WOS:000380417800010
Scopus:	2-s2.0-84973174909
Elibrary:	27099970
Chemical Abstracts:	2016:968597
PMID:	27281540
OpenAlex:	W2414965653

DB	Citing
Web of science	6
Scopus	6
Elibrary	15
OpenAlex	10