Abstract: In modern society, brain diseases belong to most frequent causes of death and reduction of the working age. For prevention and treatment of neuropathology, a variety of therapeutic and surgical approaches are being developed and improved, including radiation therapy methods. These methods have got a significant impetus to improvement through the creation of high-energy radiation sources and development of tools providing accurate targeting and strict time dosing in radiotherapy. Microbeam synchrotron radiation is one of the most promising trends in the modern radiotherapy. This technology is based on the use of synchrotron flux split into separate microbeams. Such spatial arrangement allows one to significantly amplify the dose on targets, e.g. tumors, without causing significant damage to healthy tissue. In our work we try to offer new possibilities for improving therapeutic technologies based microbeam radiation which is consists in combined use of radiotherapy and applying nanoparticles. In our experiments we used of combination of the effect of radiotherapy with saturation of tumor cell with nanoparticles of metal oxides, including particles with high catalytic activity. This combination may provide a synergistic effect for cytolysis of glioma cells based on nanoparticles enhance oxidative effect of reactive oxygen. In present time we search optimal combination of complex approach to the radio and chemo therapy of human glioma tumors.

Cite: Kuper K.E. , Moshkin M.P. , Zavjalov E.L. , Razumov I.A. , Romashchenko A. , Goldenberg B.G. , Legkodymov A.A. , Lemzyakov A.A.
Radiation Therapy of Human Glioma Tumors Experiments in SSTRC
The International Conference "Synchrotron and Free electron laser Radiation: generation and application" 04-07 Jul 2016