Реферат: Lung diseases are among the main mortality factors in the world. In the context of public health, early diagnosis of lung diseases becomes crucial. Traditional diagnostic methods such as computed tomography (CT) and spirometry, due to several limitations, cannot detect diseases at early stages. While spirometry is completely safe for humans, it cannot provide information about the internal structure of the lungs. For this purpose, CT is utilized, which uses ionizing radiation, limiting its applicability for tracking the disease progression. Magnetic resonance imaging (MRI) is a safe alternative method. It can provide information about morphological changes in the lungs and ventilation without exposure of the body to ionizing radiation. [1] Nowadays, there are several contrast agents for obtaining lung MRI with image quality comparable to CT, e.g., noble gases hyperpolarized by spin-exchange optical pumping (SEOP). However, contrast agents hyperpolarized by SEOP could not become widespread due to the complexity and high cost of the additional equipment. To overcome these limitations, the development of new methods is of considerable interest. In this work we present an approach that relies on parahydrogen-induced polarization via heterogeneous catalysts (HET-PHIP) for creating a contrast agent compatible with in vivo studies. This method does not require complex equipment for obtaining hyperpolarized gas. And in contrast to SEOP, in PHIP the polarization is observed on 1H nuclei, eliminating the need for additional coils tuned to heteronuclei. A promising gaseous contrast agent that can be created by HET-PHIP is propane (C3H8). [2] In this work, we present an approach for creating hyperpolarized propane for lung contrast in MR images, which is compatible with in vivo studies

Библиографическая ссылка: Kononenko E.S. , Trepakova A.I. , Shevelev O.B. , Kovtunova L.M. , Burueva D.B. , Koptyug I.V.
In vivo MR Imaging of Murine Bronchial Tree Using Hyperpolarized Propane Produced with Parahydrogen
21-st International School-Conference : Magnetic resonance and its applications 01-05 Apr 2024