Three-Dimensional Monte Carlo Simulations of Intracellular Diffusion and Reaction of Signaling Proteins Научная публикация
Журнал |
Journal of Chemical Physics
ISSN: 0021-9606 , E-ISSN: 1089-7690 |
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Вых. Данные | Год: 2007, Том: 127, Номер: 3, Страницы: 035101 Страниц : 4 DOI: 10.1063/1.2753159 | ||||
Ключевые слова | Genes; Monte Carlo methods; Phosphorylation; Signal transduction; Three dimensional | ||||
Авторы |
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Организации |
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Информация о финансировании (3)
1 | Swedish Research Council | |
2 | Stiftelsen för strategisk forskning | |
3 | European Commission | 505868 FP6-2002-NMP-1 STREP NANOCUES |
Реферат:
We show that the Monte Carlo technique makes it possible to perform three-dimensional simulations of intracellular protein-mediated signal transduction with realistic ratio of the rates of protein diffusion and association with genes. Specifically, we illustrate that in the simplest case when the protein degradation and phosphorylation/dephosphorylation the are negligible the distribution of the first passage time for this process is close to exponential provided that the number of target genes is between 1 and 100.
Библиографическая ссылка:
Zhdanov V.P.
Three-Dimensional Monte Carlo Simulations of Intracellular Diffusion and Reaction of Signaling Proteins
Journal of Chemical Physics. 2007. V.127. N3. P.035101. DOI: 10.1063/1.2753159 WOS Scopus РИНЦ
Three-Dimensional Monte Carlo Simulations of Intracellular Diffusion and Reaction of Signaling Proteins
Journal of Chemical Physics. 2007. V.127. N3. P.035101. DOI: 10.1063/1.2753159 WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 27 мар. 2007 г. |
Принята к публикации: | 4 июн. 2007 г. |
Опубликована online: | 16 июл. 2007 г. |
Опубликована в печати: | 21 июл. 2007 г. |
Идентификаторы БД:
Web of science | WOS:000248194300041 |
Scopus | 2-s2.0-34547187550 |
РИНЦ | 13545413 |
Chemical Abstracts | 2007:833299 |
Chemical Abstracts (print) | 147:316560 |
OpenAlex | W2014477193 |