Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Переводная
|
| Журнал |
Angewandte Chemie - International Edition
ISSN: 1433-7851
, E-ISSN: 1521-3773
|
| Вых. Данные |
Год: 2017,
Том: 56,
Номер: 35,
Страницы: 10433-10437
Страниц
: 5
DOI:
10.1002/anie.201705014
|
| Ключевые слова |
het-SABRE, heterogeneous catalysis, heteronuclei, hyperpolarization, parahydrogen |
| Авторы |
Kovtunov Kirill V.
1,2
,
Kovtunova Larisa M.
2,3
,
Gemeinhardt Max E.
4
,
Bukhtiyarov Andrey V.
3
,
Gesiorski Jonathan
4
,
Bukhtiyarov Valerii I.
3
,
Chekmenev Eduard Y.
6,7,8,9
,
Koptyug Igor V.
1,2
,
Goodson Boyd
4,5
|
| Организации |
| 1 |
Laboratory of Magnetic Resonance Microimaging, International Tomography Center, SB RAS, 3A Institutskaya St., Novosibirsk 630090 (Russia)
|
| 2 |
Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090 (Russia)
|
| 3 |
Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., Novosibirsk 630090 (Russia)
|
| 4 |
Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL 62901 (United States)
|
| 5 |
Materials Technology Center, Southern Illinois University, Carbondale, IL 62901 (United States)
|
| 6 |
Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Nashville, Tennessee, 37232-2310 (United States)
|
| 7 |
Department of Biomedical Engineering, VICC, Nashville, Tennessee, 37232-2310 (United States)
|
| 8 |
Department of Physics and Astronomy, Nashville, Tennessee, 37232-2310 (United States)
|
| 9 |
Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow (Russia)
|
|
Информация о финансировании (13)
|
1
|
Российский научный фонд
|
14-23-00146
|
|
2
|
Российский фонд фундаментальных исследований
|
16-03-00407
|
|
3
|
Министерство образования и науки Российской Федерации
|
МК-4498.2016.3
|
|
4
|
National Institutes of Health
|
1R21EB018014
|
|
5
|
National Institutes of Health
|
1R21EB020323
|
|
6
|
National Science Foundation
|
CHE-1416268
|
|
7
|
United States Department of Defense
|
W81XWH-12-1-0159/BC112431
|
|
8
|
United States Department of Defense
|
W81XWH-15-1-0271
|
|
9
|
National Science Foundation
|
CHE-1416432
|
|
10
|
ExxonMobil
|
|
|
11
|
United States Department of Defense
|
W81XWH-15-1-0272
|
|
12
|
Федеральное агентство научных организаций России
|
V.44.1.8. (0333-2016-0001)
|
|
13
|
Российский фонд фундаментальных исследований
|
17-54-33037
|
The hyperpolarization of heteronuclei via Signal Amplification by Reversible Exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes = 1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD = cyclooctadiene] catalyst onto silica particles modified with NH2(CH2)3- linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate ~102-fold enhancement of 15N NMR signals in pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XRD characterization, supports that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.