Non-Coding RNAs and Complex Distributed Genetic Networks Научная публикация
Журнал |
Central European Journal of Physics
ISSN: 1895-1082 , E-ISSN: 1644-3608 |
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Вых. Данные | Год: 2011, Том: 9, Номер: 4, Страницы: 909-918 Страниц : 10 DOI: 10.2478/s11534-010-0104-y | ||||
Ключевые слова | association of mRNA and ncRNA, bistability and scillations, gene transcription, mean-field kinetic equations, mRNA translation | ||||
Авторы |
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Организации |
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Реферат:
In eukaryotic cells, the mRNA-protein interplay can be dramatically influenced by non-coding RNAs (ncRNAs). Although this new paradigm is now widely accepted, an understanding of the effect of ncRNAs on complex genetic networks is lacking. To clarify what may happen in this case, we propose a mean-field kinetic model describing the influence of ncRNA on a complex genetic network with a distributed architecture including mutual protein-mediated regulation of many genes transcribed into mRNAs. ncRNA is considered to associate with mRNAs and inhibit their translation and/or facilitate degradation. Our results are indicative of the richness of the kinetics under consideration. The main complex features are found to be bistability and oscillations. One could expect to find kinetic chaos as well. The latter feature has however not been observed in our calculations. In addition, we illustrate the difference in the regulation of distributed networks by mRNA and ncRNA.
Библиографическая ссылка:
Zhdanov V.P.
Non-Coding RNAs and Complex Distributed Genetic Networks
Central European Journal of Physics. 2011. V.9. N4. P.909-918. DOI: 10.2478/s11534-010-0104-y WOS Scopus РИНЦ
Non-Coding RNAs and Complex Distributed Genetic Networks
Central European Journal of Physics. 2011. V.9. N4. P.909-918. DOI: 10.2478/s11534-010-0104-y WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 13 июн. 2010 г. |
Принята к публикации: | 8 окт. 2010 г. |
Опубликована online: | 30 апр. 2011 г. |
Опубликована в печати: | 1 авг. 2011 г. |
Идентификаторы БД:
Web of science | WOS:000290035200002 |
Scopus | 2-s2.0-79955596924 |
РИНЦ | 17003411 |
Chemical Abstracts | 2011:543947 |
Chemical Abstracts (print) | 158:293180 |
OpenAlex | W2073645670 |