Direct Comparison Between Apparent Diffusion Coefficient and Macromolecular Proton Fraction as Quantitative Biomarkers of the Human Fetal Brain Maturation Научная публикация
Журнал |
Journal Of Magnetic Resonance Imaging
ISSN: 1053-1807 , E-ISSN: 1522-2586 |
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Вых. Данные | Год: 2019, Том: 50, Номер: 1, Страницы: 52-61 Страниц : 10 DOI: 10.1002/jmri.26635 | ||||||
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Реферат:
Background: Apparent diffusion coefficient (ADC) is known as a quantitative biomarker of prenatal brain maturation. Fast macromolecular proton fraction (MPF) mapping is an emerging method for quantitative assessment of myelination that was recently adapted to fetal MRI.
Purpose: To compare the capability of ADC and MPF to quantify the normal fetal brain development.
Study type: Prospective.
Population: Forty-two human fetuses in utero (gestational age [GA] = 27.7 ± 6.0, range 20-38 weeks).
Field strength/sequence: 1.5 T; diffusion-weighted single-shot echo-planar spin-echo with five b-values for ADC mapping; spoiled multishot echo-planar gradient-echo with T1 , proton density, and magnetization transfer contrast weightings for single-point MPF mapping.
Assessment: Two operators measured ADC and MPF in the medulla, pons, cerebellum, thalamus, and frontal, occipital, and temporal cerebral white matter (WM).
Statistical tests: Mixed repeated-measures analysis of variance (ANOVA) with the factors of pregnancy trimester and brain structure; Pearson correlation coefficient (r); Hotelling-Williams test to compare strengths of correlations.
Results: From the 2nd to 3rd trimester, ADC significantly decreased in the thalamus and cerebellum (P < 0.005). MPF significantly increased in the medulla, pons, thalamus, and cerebellum (P < 0.005). Cerebral WM had significantly higher ADC and lower MPF compared with the medulla and pons in both trimesters. MPF (r range 0.83, 0.89, P < 0.001) and ADC (r range -0.43, -0.75, P ≤ 0.004) significantly correlated with GA and each other (r range -0.32, -0.60, P ≤ 0.04) in the medulla, pons, thalamus, and cerebellum. No significant correlations or distinctions between regions and trimesters were observed for cerebral WM (P range 0.1-0.75). Correlations with GA were significantly stronger for MPF compared with ADC in the medulla, pons, and cerebellum (Hotelling-Williams test, P < 0.003) and similar in the thalamus. Structure-averaged MPF and ADC values strongly correlated (r = 0.95, P < 0.001).
Библиографическая ссылка:
Korostyshevskaya A.M.
, Prihod’ko I.Y.
, Savelov A.A.
, Yarnykh V.L.
Direct Comparison Between Apparent Diffusion Coefficient and Macromolecular Proton Fraction as Quantitative Biomarkers of the Human Fetal Brain Maturation
Journal Of Magnetic Resonance Imaging. 2019. V.50. N1. P.52-61. DOI: 10.1002/jmri.26635 Scopus
Direct Comparison Between Apparent Diffusion Coefficient and Macromolecular Proton Fraction as Quantitative Biomarkers of the Human Fetal Brain Maturation
Journal Of Magnetic Resonance Imaging. 2019. V.50. N1. P.52-61. DOI: 10.1002/jmri.26635 Scopus
Даты:
Опубликована online: | 11 янв. 2019 г. |
Идентификаторы БД:
Scopus | 2-s2.0-85059912385 |
PMID (PubMed) | 30635965 |
OpenAlex | W2910088319 |