Multi-Walled Carbon Nanotubes Increase Anxiety Levels in Rats and Reduce Exploratory Activity in the Open Field Test
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Переводная
|
| Журнал |
Doklady Biological Sciences
ISSN: 0012-4966
, E-ISSN: 1608-3105
|
| Вых. Данные |
Год: 2015,
Том: 464,
Номер: 1,
Страницы: 223-225
Страниц
: 3
DOI:
10.1134/S0012496615050026
|
| Авторы |
Sayapina N.V.
1
,
Batalova T.A.
1
,
Chaika V.V.
3
,
Kuznetsov V.L.
2
,
Sergievich A.A.
3
,
Kolosov V.P.
4
,
Perelʹman Yu.M.
1
,
Golokhvast K.S.
3
|
| Организации |
| 1 |
Amur State Medical Academy, Blagoveshchensk, 675000, Russia
|
| 2 |
Far East Scientific Center for the Physiology and Pathology of Respiration, Blagoveshchensk, 675000 Russia
|
| 3 |
Far East Federal University, Vladivostok, 690001 Russia
|
| 4 |
Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia
|
|
Информация о финансировании (2)
|
1
|
Федеральное агентство научных организаций России
|
V.45.3.5.
|
|
2
|
Дальневосточный федеральный университет
|
13-06-0318
|
The results of the first study on the effects of multi-walled carbon nanotubes (MWNTs) on the exploratory activity and the emotional state in laboratory rats assessed by the open field test are reported. During three or ten days, rats received 8–10 nm MWNTs added to their food at a dose of 500 mg/kg. It was demonstrated that, in the group of rats which were fed with MWNTs, the integrated anxiety level index began to increase as early as the third day of the experiment; on the tenth day, it appeared to be twice increased. It was also demonstrated that MWNTs decreased the integrated exploratory activity index nearly twofold on the third day and nearly fourfold on the tenth day.