Preparative Procedure for the Synthesis of 4-Allyloxypyridine-2,6-dicarboxylic Acid
Russian Journal of Organic Chemistry
, E-ISSN: 1608-3393
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090 Russia
Novosibirsk State University, Novosibirsk, Russia
St. Petersburg Division, Boreskov Institute of Catalysis, Siberian Division, Russian Academy of Sciences, St. Petersburg, Russia
The authors describe the preparative procedure for the synthesis of 4-allyloxypyridine-2,6-dicarboxylic acid. The acid 4-allyloxypyridine-2,6-dicarboxylic acid is used as starting compound in the synthesis of 4-allyloxy-2,6-diacetylpyridine. The authors found that acid can be synthesized in two steps and that its yield can be raised to 89% by carrying out alkylation of anhydrous dicarboxylic acid with allyl bromide in the presence of anhydrous potassium carbonate in a mixture of acetone.