Unusual Seeding Effect in the Liquid-Assisted High-Pressure Polymorphism of Chlorpropamide
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, ul. Kutateladze, 18, Novosibirsk, Russian Federation
Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, Russian Federation
V.S. Sobolev Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, pr. Acad. Koptyug 3, Novosibirsk, Russian Federation
© The Royal Society of Chemistry 2016.When crystals of four polymorphs-a stable α-form and three metastable ones (β-, γ-, δ-forms)-are simultaneously present in a pressure cell, immersed in a 1:1 pentane-isopentane mixture, the least stable β-form recrystallises exclusively into the γ-form (if no δ-form seed is present) or concomitantly into the γ- and δ-forms (if a seed of the δ-form is present). However, the β-form never recrystallises to the stable α-form, even if the latter is also present as a potential seed.