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Thermodynamic Aspects of Freeze-Drying: A Case Study of an “Organic Solvent–Water” System Full article

Общее Language: Английский, Genre: Full article,
Status: Published, Source type: Original
Journal Journal of Thermal Analysis and Calorimetry
ISSN: 1388-6150 , E-ISSN: 1572-8943
Output data Year: 2017, Volume: 127, Number: 2, Pages: 1593-1604 Pages count : 12 DOI: 10.1007/s10973-016-6003-8
Tags Cryotemperature SEM, DSC, Freeze-drying, Phase diagram, X-ray diffraction
Authors Ogienko A.G. 1,2 , Drebushchak V.A. 2,3 , Bogdanova E.G. 1,2 , Yunoshev A.S. 2,4 , Ogienko A.A. 5 , Boldyreva E.V. 6 , Manakov A.Y. 1,2
Affiliations
1 Nikolaev Institute of Inorganic Chemistry SB RAS, Lavrentiev Ave. 3, Novosibirsk, Russia 630090
2 Novosibirsk State University, ul. Pirogova 2, Novosibirsk, Russia 630090
3 Sobolev Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russia 630090
4 Lavrentiev Institute of Hydrodynamics SB RAS, Novosibirsk, Russia 630090
5 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 630090
6 Institute of Solid State Chemistry and Mechanochemistry SB RAS, ul. Kutateladze 18, Novosibirsk, Russia 630128

Funding (4)

1 The Ministry of Education and Science of the Russian Federation СП-1144.2013.4
2 The Ministry of Education and Science of the Russian Federation СП-680.2013.4
3 Federal Agency for Scientific Organizations 0301-2014-0002
4 Federal Agency for Scientific Organizations 0330-2016-0004 (АААА-А17-117122790027-1)

Abstract: Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation.
Cite: Ogienko A.G. , Drebushchak V.A. , Bogdanova E.G. , Yunoshev A.S. , Ogienko A.A. , Boldyreva E.V. , Manakov A.Y.
Thermodynamic Aspects of Freeze-Drying: A Case Study of an “Organic Solvent–Water” System
Journal of Thermal Analysis and Calorimetry. 2017. V.127. N2. P.1593-1604. DOI: 10.1007/s10973-016-6003-8 publication_identifier_short.wos_identifier_type publication_identifier_short.scopus_identifier_type
Dates:
Submitted: Jun 23, 2016
Accepted: Nov 25, 2016
Published online: Dec 19, 2016
Published print: Feb 1, 2017
Identifiers:
publication_identifier.wos_identifier_type WOS:000394142200045
publication_identifier.scopus_identifier_type 2-s2.0-85006486804
publication_identifier.accession_number_identifier_type 2016:2132412
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