Catalytic Hydrodefluorination of Polycyclic α,α-Difluoroketones Conference Abstracts
Conference |
EuropaCat-XIII: 13th European Congress on Catalysis 27-31 Aug 2017 , Florence |
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Source | 13th European Congress on Catalysis Compilation, 2017. |
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Output data | Year: 2017, Article number : P2.214, Pages count : 2 | ||||
Authors |
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Affiliations |
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Funding (1)
1 | Russian Foundation for Basic Research | 16-33-00944 (АААА-А16-116012110298-0) |
Abstract:
Catalytic hydrodefluorination of polycyclic α,α-difluoroketones derived from naphthalene and tetraphene was investigated. The mechanism of catalytic reaction was explored by comparison with results of stoichiometric reduction and determination of the structures of intermediates formed. Reduction of -CF2-CO moiety into –CF-COH fragment in naphthalene and tetraphene backbones was performed under hydrogen
atmosphere on palladium catalysts and with sodium borohydride followed by basic workup. Formation of an intermediate containing –CF2-CHOH group was observed in both cases suggesting similar two-stage mechanistic pathways for these reduction methods. Catalytic reduction of 1,1-difluoronaphthalene-2(1H)-one into corresponding 1-fluoronaphth-2-ol proceeds with quantitative yield in mild conditions making it a
promising method for synthesis of fluorinated aromatic compounds from α,α-difluoroketones.
Cite:
Dyan O.T.
, Kulagina M.A.
, Zaikin P.A.
Catalytic Hydrodefluorination of Polycyclic α,α-Difluoroketones
In compilation 13th European Congress on Catalysis. 2017. – C.416-417.
Catalytic Hydrodefluorination of Polycyclic α,α-Difluoroketones
In compilation 13th European Congress on Catalysis. 2017. – C.416-417.
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