A Quantum-Chemical Model of the Inhibition Mechanism of viral DNA HIV-1 Replication by Iodine Complex Compounds Full article
Journal |
Natural Science
ISSN: 2150-4091 , E-ISSN: 2150-4105 |
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Output data | Year: 2011, Volume: 03, Number: 07, Pages: 573-579 Pages count : 7 DOI: 10.4236/ns.2011.37080 | ||||
Tags | HIV; Integrase HIV; Quantum-Chemical Method Ab Initio | ||||
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Abstract:
The interaction of molecular iodine with virus DNA nucleotide is studied by ab initio RHF/3-21G** method. Formation of the nucleoprotein complex of the HIV DNA, molecular iodine and the HIV-1 integrase co-factor is considered to cause the inhibition action of the integrase enzyme. Experimental data on the anti-HIV effect of the molecular iodine complex compounds and the results of calculations suggest that molecular iodine contained in iodine polymer complexes may be considered as a compound inhibiting the catalytic center of the integrase enzyme. Unlike the known integrase inhibitors, molecular iodine also changes the virus DNA structure and produces the N-I bond in the purine bases of adenosine and guanosine nucleotides.
Cite:
Yuldasheva G.A-R.
, Zhidomirov G.M.
, Ilin A.I.
A Quantum-Chemical Model of the Inhibition Mechanism of viral DNA HIV-1 Replication by Iodine Complex Compounds
Natural Science. 2011. V.03. N07. P.573-579. DOI: 10.4236/ns.2011.37080
A Quantum-Chemical Model of the Inhibition Mechanism of viral DNA HIV-1 Replication by Iodine Complex Compounds
Natural Science. 2011. V.03. N07. P.573-579. DOI: 10.4236/ns.2011.37080
Dates:
Submitted: | Mar 21, 2011 |
Accepted: | Apr 21, 2011 |
Identifiers:
OpenAlex | W2008365726 |
Citing:
DB | Citing |
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OpenAlex | 4 |