Simulations of Temperature Dependence of the Formation of a Supported Lipid Bilayer via Vesicle Adsorption Full article
Journal |
Colloids and Surfaces B: Biointerfaces
ISSN: 0927-7765 , E-ISSN: 1873-4367 |
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Output data | Year: 2004, Volume: 39, Number: 1-2, Pages: 77-86 Pages count : 10 DOI: 10.1016/j.colsurfb.2004.09.003 | ||||
Tags | Adsorption kinetics, Bilayer formation, Critical surface coverage, Monte Carlo simulations, Supported lipid bilayer, Vesicle adsorption | ||||
Authors |
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Affiliations |
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Funding (2)
1 | Swedish Research Council | Dnr 621-2001-2649 |
2 | VINNOVA | 2002-01238 |
Abstract:
Recent experimental investigations of the kinetics of vesicle adsorption in solution on SiO2 demonstrate a thermally activated transition from adsorbed intact vesicles to a supported lipid bilayer. Our Monte Carlo simulations clarify the mechanism of this process. The model employed is an extension of the model used earlier to describe vesicle adsorption at room temperature. Specifically, it includes limitations of the adsorption rate by vesicle diffusion in the solution, and adsorption- and lipid-membrane-induced rupture of arriving and already adsorbed vesicles. Vesicles and lipid molecules, formed after rupture of vesicles, are considered immobile. With these ingredients, the model is able to quantitatively reproduce the temperature-dependent adsorption kinetics, including a higher critical surface concentration of intact vesicles for lower temperatures, and the apparent activation energy for the vesicle-to-bilayer transition Ea≃5 kcal/mol.
Cite:
Dimitrievski K.
, Reimhult E.
, Kasemo B.H.
, Zhdanov V.P.
Simulations of Temperature Dependence of the Formation of a Supported Lipid Bilayer via Vesicle Adsorption
Colloids and Surfaces B: Biointerfaces. 2004. V.39. N1-2. P.77-86. DOI: 10.1016/j.colsurfb.2004.09.003 WOS Scopus РИНЦ
Simulations of Temperature Dependence of the Formation of a Supported Lipid Bilayer via Vesicle Adsorption
Colloids and Surfaces B: Biointerfaces. 2004. V.39. N1-2. P.77-86. DOI: 10.1016/j.colsurfb.2004.09.003 WOS Scopus РИНЦ
Dates:
Submitted: | May 28, 2004 |
Accepted: | Sep 16, 2004 |
Published online: | Oct 27, 2004 |
Published print: | Nov 25, 2004 |
Identifiers:
Web of science | WOS:000225385500012 |
Scopus | 2-s2.0-8144228650 |
Elibrary | 13448201 |
Chemical Abstracts | 2004:977940 |
Chemical Abstracts (print) | 142:350927 |
OpenAlex | W2001983136 |