Protonation Site and Hydrogen Bonding in Anhydrous and Hydrated Crystalline Forms of Doxazosin Mesylate from Powder Data Full article
Journal |
Acta Crystallographica Section B. Structural Science (up to 2013)
ISSN: 0108-7681 , E-ISSN: 1600-5740 |
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Output data | Year: 2003, Volume: 59, Number: 6, Pages: 787-793 Pages count : 7 DOI: 10.1107/S0108768103022729 | ||||||||||
Tags | Composition; Dissolution; Hydration; Hydrogen bonds; Methanol; Mixtures; Protons; Solutions; Synthesis (chemical) | ||||||||||
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Abstract:
The three-dimensional solid-state structures of two modifications of doxazosin mesylate C23H26N5O_5^+·CH3SO_3^-, 4-amino-2-[4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate, a commonly used antihypertensive agent, have been determined by synchrotron X-ray powder diffraction. An anhydrous form (A) and a dihydrate form (dG) crystallize in monoclinic space groups. In both forms the doxazosin molecule is protonated at the N1 atom of the quinazoline bicycle. The N1 atom, and the amino H atoms and O atoms of the mesylate moieties are involved in three-dimensional hydrogen-bonding networks, while solvent water molecules and carboxamide O atoms are also incorporated in a hydrogen-bonding network in dG.
Cite:
Chernyshev V.V.
, Machon D.
, Fitch A.N.
, Zaitsev S.A.
, Yatsenko A.V.
, Shmakov A.N.
, Weber H-P.
Protonation Site and Hydrogen Bonding in Anhydrous and Hydrated Crystalline Forms of Doxazosin Mesylate from Powder Data
Acta Crystallographica Section B. Structural Science (up to 2013). 2003. V.59. N6. P.787-793. DOI: 10.1107/S0108768103022729 WOS Scopus РИНЦ
Protonation Site and Hydrogen Bonding in Anhydrous and Hydrated Crystalline Forms of Doxazosin Mesylate from Powder Data
Acta Crystallographica Section B. Structural Science (up to 2013). 2003. V.59. N6. P.787-793. DOI: 10.1107/S0108768103022729 WOS Scopus РИНЦ
Dates:
Submitted: | Jul 10, 2003 |
Accepted: | Oct 9, 2003 |
Published online: | Nov 25, 2003 |
Published print: | Dec 1, 2003 |
Identifiers:
Web of science | WOS:000186768900011 |
Scopus | 2-s2.0-2542506555 |
Elibrary | 13439474 |
Chemical Abstracts | 2003:916057 |
Chemical Abstracts (print) | 140:243792 |
OpenAlex | W1987096016 |