Kinetics of Enzyme-Mediated Hydrolysis of Lipid Vesicles | Sciact - CRIS-system of Boreskov Institute of Catalysis

Kinetics of Enzyme-Mediated Hydrolysis of Lipid Vesicles Full article

Journal

Chemical Physics Letters
ISSN: 0009-2614 , E-ISSN: 1873-4448

Output data

Year: 2016, Volume: 663, Pages: 51-56 Pages count : 6 DOI: 10.1016/j.cplett.2016.09.018

Tags

Enzymatic catalysis, Lipid membranes, Mean-field kinetic equations, Monte Carlo simulations, Stochastic kinetics

Authors

Zhdanov Vladimir P. ^1,2 , Agnarsson Björn ¹ , Höök Fredrik ¹

Affiliations

1	Division of Biological Physics, Department of Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden
2	Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia

Funding (1)

Swedish Research Council

2013-7421

Membrane enzymatic reactions can now be experimentally studied at the level of single sub-100 nm lipid vesicles. To interpret such experiments, we scrutinize theoretically various aspects of the hydrolysis of vesicles by single enzyme molecules and enzyme (e.g., PLA2) supplied with the constant rate. Using the mean-field kinetic model, we illustrate the shape of the corresponding kinetics and the dependence of the time scale of the reaction on the vesicle radius. Stochastic effects are illustrated as well. In addition, we discuss the likely mechanisms of the reaction-induced pore formation and bilayer rupture

Zhdanov V.P. , Agnarsson B. , Höök F.
Kinetics of Enzyme-Mediated Hydrolysis of Lipid Vesicles
Chemical Physics Letters. 2016. V.663. P.51-56. DOI: 10.1016/j.cplett.2016.09.018 WOS Scopus РИНЦ ANCAN OpenAlex

Submitted:	Jul 28, 2016
Accepted:	Sep 10, 2016
Published online:	Sep 15, 2016
Published print:	Oct 16, 2016

Web of science:	WOS:000387193100009
Scopus:	2-s2.0-84988822552
Elibrary:	27569326
Chemical Abstracts:	2016:1588504
Chemical Abstracts (print):	165:413440
OpenAlex:	W2519720796

DB	Citing
Scopus	1
Elibrary	1
OpenAlex	1