Interpretation of Amperometric Kinetics of Content Release During Contacts of Vesicles with a Lipid Membrane Научная публикация
| Журнал |
European Biophysics Journal with Biophysics Letters
ISSN: 0175-7571 , E-ISSN: 1432-1017 |
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| Вых. Данные | Год: 2017, Том: 46, Номер: 5, Страницы: 461-470 Страниц : 10 DOI: 10.1007/s00249-016-1189-z | ||||
| Ключевые слова | Amperometric spikes, Exocytosis, Lipid bilayers, Pore formation, Subcellular processes, Vesicles | ||||
| Авторы |
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| Организации |
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Реферат:
The exocytotic pathway of secretion of molecules from cells includes transport by vesicles, tether-mediated fusion of vesicles with the plasma membrane accompanied by pore formation, and diffusion-mediated release of their contents via a pore to the outside. In related basic biophysical studies, vesicle-content release is tracked by measuring corresponding amperometric spikes. Although experiments of this type have a long history, the understanding of the underlying physics is still elusive. The present study elucidates the likely contribution of line energy, membrane tension and bending, osmotic pressure, hydration forces, and tethers to the potential energy for fusion-related pore formation and evolution. The overdamped Langevin equation is used to describe the pore dynamics, which are in turn employed to calculate the kinetics of content release and to interpret the shape of amperometric spikes.
Библиографическая ссылка:
Zhdanov V.P.
Interpretation of Amperometric Kinetics of Content Release During Contacts of Vesicles with a Lipid Membrane
European Biophysics Journal with Biophysics Letters. 2017. V.46. N5. P.461-470. DOI: 10.1007/s00249-016-1189-z WOS Scopus РИНЦ CAPlus PMID OpenAlex
Interpretation of Amperometric Kinetics of Content Release During Contacts of Vesicles with a Lipid Membrane
European Biophysics Journal with Biophysics Letters. 2017. V.46. N5. P.461-470. DOI: 10.1007/s00249-016-1189-z WOS Scopus РИНЦ CAPlus PMID OpenAlex
Даты:
| Поступила в редакцию: | 14 июл. 2016 г. |
| Принята к публикации: | 28 нояб. 2016 г. |
| Опубликована online: | 10 дек. 2016 г. |
| Опубликована в печати: | 1 июл. 2017 г. |
Идентификаторы БД:
| Web of science: | WOS:000403429900006 |
| Scopus: | 2-s2.0-85006391506 |
| РИНЦ: | 31018533 |
| Chemical Abstracts: | 2016:2080954 |
| PMID (PubMed): | 27942741 |
| OpenAlex: | W2560769225 |