Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells | Sciact - CRIS-система Института катализа

Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 , E-ISSN: 1573-8221

Вых. Данные

Год: 2017, Том: 163, Номер: 4, Страницы: 561-565 Страниц : 5 DOI: 10.1007/s10517-017-3849-0

Ключевые слова

glioblastoma, manganese nanoparticles, MTT test, U-251, U-87MG

Авторы

Razumov I.A. ¹ , Zav’yalov E.L. ¹ , Troitskii S.Yu. ² , Romashchenko A.V. ¹ , Petrovskii D.V. ¹ , Kuper K.E. ³ , Moshkin M.P. ¹

Организации

1	Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
2	G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences
3	G. I. Budker Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

Информация о финансировании (2)

1	Российский научный фонд	14-50-00080
2	Российский научный фонд	14-14-00221

Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС50 for tumor cells. Five of 6 samples of tested nanoparticles demonstrated selective toxic effect in vitro. Manganese oxide nanoparticles were characterized by maximum selectivity (СС50 6.9 nM and 2.1 nM for U-87MG and U-251 cells, respectively): selectivity index for glioblastoma U-87MG and U-251 cells was 29 and 95.2, respectively. Manganese oxide nanoparticles used for MRI detection of gliomas can be used for designing an oncolytic agent for the treatment of glial tumors in humans.

Razumov I.A. , Zav’yalov E.L. , Troitskii S.Y. , Romashchenko A.V. , Petrovskii D.V. , Kuper K.E. , Moshkin M.P.
Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells
Bulletin of Experimental Biology and Medicine. 2017. V.163. N4. P.561-565. DOI: 10.1007/s10517-017-3849-0 WOS Scopus РИНЦ CAPlus PMID OpenAlex

Разумов И.А. , Завьялов Е.Л. , Троицкий С.Ю. , Ромащенко А.В. , Петровский Д.В. , Купер К.Э. , Мошкин М.П.
Избирательная цитотоксичность наночастиц марганца в отношении клеток глиобластом человека
Клеточные технологии в биологии и медицине. 2017. №2. С.114-118. РИНЦ

Поступила в редакцию:	6 дек. 2016 г.
Опубликована в печати:	1 авг. 2017 г.
Опубликована online:	29 авг. 2017 г.

Web of science:	WOS:000409342400035
Scopus:	2-s2.0-85028768777
РИНЦ:	31117618
Chemical Abstracts:	2017:1481442
PMID (PubMed):	28853080
OpenAlex:	W2752643534

БД	Цитирований
Web of science	15
Scopus	16
РИНЦ	16
OpenAlex	17