First Evidence of Polymorphism in Furosemide Solvates | Sciact - CRIS-система Института катализа

First Evidence of Polymorphism in Furosemide Solvates Научная публикация

Журнал

Crystal Growth and Design
ISSN: 1528-7483 , E-ISSN: 1528-7505

Вых. Данные

Год: 2017, Том: 17, Номер: 5, Страницы: 2333-2341 Страниц : 9 DOI: 10.1021/acs.cgd.6b01191

Ключевые слова

Dimethyl sulfoxide; Molecular orientation; Molecules; Ambient conditions; Anti-solvents; Desolvation; Dimethyl sulfoxide (DMSO); Furosemides; Molecular packings; Rapid crystallization; Solvent molecules

Авторы

Beloborodova Alina A. ^1,2 , Minkov Vasily S. ³ , Rychkov Denis A. ^1,4 , Rybalova Tatyana V. ^1,2 , Boldyreva Elena V. ^1,4

Организации

1	Novosibirsk State University, Novosibirsk, Russian Federation
2	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk, Russian Federation
3	Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, Mainz, Germany
4	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk, Russian Federation

Информация о финансировании (1)

Министерство образования и науки Российской Федерации

1828

Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules - DMSO and DMF - is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions.

Beloborodova A.A. , Minkov V.S. , Rychkov D.A. , Rybalova T.V. , Boldyreva E.V.
First Evidence of Polymorphism in Furosemide Solvates
Crystal Growth and Design. 2017. V.17. N5. P.2333-2341. DOI: 10.1021/acs.cgd.6b01191 WOS Scopus CAPlusCA OpenAlex

Поступила в редакцию:	9 авг. 2016 г.
Принята к публикации:	17 мар. 2017 г.
Опубликована online:	29 мар. 2017 г.
Опубликована в печати:	3 мая 2017 г.

Web of science:	WOS:000400802500006
Scopus:	2-s2.0-85018979750
Chemical Abstracts:	2017:476621
Chemical Abstracts (print):	166:427623
OpenAlex:	W2598497561

БД	Цитирований
Web of science	16
Scopus	17
OpenAlex	20