Crystal Structure of a 2:1 Co-crystal of Meloxicam with Acetylendicarboxylic Acid | Sciact - CRIS-система Института катализа

Crystal Structure of a 2:1 Co-crystal of Meloxicam with Acetylendicarboxylic Acid Научная публикация

Журнал

Acta Crystallographica Section E
, E-ISSN: 2056-9890

Вых. Данные

Год: 2016, Том: 72, Номер: 12, Страницы: 1856-1859 Страниц : 4 DOI: 10.1107/s2056989016018909

Ключевые слова

acetylenedicarboxylic acid, co-crystal, crystal structure, dicarboxylic acid, drugs, hydrogen bonds, meloxicam, oxicam

Авторы

Tantardini Christian ¹ , Arkhipov Sergey G. ^1,2 , Cherkashina Ksenya A. ^1,2 , Kil'met'ev Alexander S. ^1,3 , Boldyreva Elena V. ²

Организации

1	Novosibirsk State University, Pirogova str. 2, Novosibirsk, Russian Federation
2	Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze str. 18, Novosibirsk, Russian Federation
3	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev str. 9, Novosibirsk, Russian Federation

The pharmaceutical 2:1 co-crystal of meloxicam [MXM; systematic name: 4-hydroxy-2-methyl-N-(5-methylthiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide] with acetylenedicarboxylic acid (ACA; systematic name: but-2-ynedioic acid), crystallizes with one MXM molecule and half an ACA molecule in the asymmetric unit, C14H13N3O4S2 0.5C4H2O4. The mid-point of the triple bond of ACA is located on an inversion centre. In the crystal, the two stereoisomers of MXM with respect to the N atom of the sulfonamide group are related by the inversion centre. The carbonyl and hydroxy groups belonging to the MXM molecule are involved in an intramolecular O - H⋯O hydrogen bond. The structure-forming motif includes two MXM molecules linked via an ACA conformer through N - H⋯O and O - H⋯N hydrogen bonds, similar to MXM co-crystals with other dicarboxylic acids.

Tantardini C. , Arkhipov S.G. , Cherkashina K.A. , Kil'met'ev A.S. , Boldyreva E.V.
Crystal Structure of a 2:1 Co-crystal of Meloxicam with Acetylendicarboxylic Acid

Acta Crystallographica Section E. 2016. V.72. N12. P.1856-1859. DOI: 10.1107/s2056989016018909 WOS Scopus РИНЦ CAPlus OpenAlex

Полный текст от издателя

Поступила в редакцию:	8 нояб. 2016 г.
Принята к публикации:	26 нояб. 2016 г.
Опубликована online:	29 нояб. 2016 г.
Опубликована в печати:	1 дек. 2016 г.

Web of science:	WOS:000390315400042
Scopus:	2-s2.0-85003587490
РИНЦ:	29463888
Chemical Abstracts:	2016:2008727
OpenAlex:	W2559147521

БД	Цитирований
Scopus	11
Web of science	13
OpenAlex	12