The Effect of Carboxylic Acids on Glycine Polymorphism, Salt and Co-crystal Formation. A Comparison of Different Crystallisation Techniques Научная публикация
| Журнал |
New Journal of Chemistry
ISSN: 1144-0546 , E-ISSN: 1369-9261 |
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| Вых. Данные | Год: 2013, Том: 37, Номер: 7, Страницы: 1973-1981 Страниц : 9 DOI: 10.1039/c3nj41169a | ||||
| Ключевые слова | BETA-GLYCINE; TAILOR-MADE; THERMODYNAMIC ASPECTS; SOLUTION CHEMISTRY; PHASE-TRANSITION; CHARGE-TRANSFER; ALPHA-GLYCINE; AMINO-ACIDS; GROWTH; GAMMA-glycine | ||||
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Реферат:
The effect of carboxylic acids on glycine polymorphism, salt and co-crystal formation was compared for slow evaporation of solutions at ambient conditions, spray drying, “fast” and “slow” anti-solvent crystallisation and dry co-grinding. Different phases were found to crystallise from the same starting components, depending on the preparative technique. Small amounts of most carboxylic acids (glutaric acid being the only exception) promoted crystallisation of the γ-polymorph in solution and as a result of co-grinding. When added in equimolar quantities, the same carboxylic acids formed salts with glycine (addition of glutaric acid resulted in co-crystal formation) on slow evaporation of solutions and on co-grinding. Neither succinic nor L-malic acids produced glycine salts, but instead promoted formation of γ-glycine when present in any amount. Anti-solvent crystallisation and spray drying of solutions containing small or large amounts of carboxylic acids produced a variety of glycine polymorphs as both pure phases and their mixtures, whereas only oxalic acid yielded salts. The ability to synthesise glycinium semi-oxalate form II by spray drying was demonstrated.
Библиографическая ссылка:
Losev E.A.
, Mikhailenko M.A.
, Achkasov A.F.
, Boldyreva E.V.
The Effect of Carboxylic Acids on Glycine Polymorphism, Salt and Co-crystal Formation. A Comparison of Different Crystallisation Techniques
New Journal of Chemistry. 2013. V.37. N7. P.1973-1981. DOI: 10.1039/c3nj41169a WOS Scopus РИНЦ CAPlusCA OpenAlex
The Effect of Carboxylic Acids on Glycine Polymorphism, Salt and Co-crystal Formation. A Comparison of Different Crystallisation Techniques
New Journal of Chemistry. 2013. V.37. N7. P.1973-1981. DOI: 10.1039/c3nj41169a WOS Scopus РИНЦ CAPlusCA OpenAlex
Даты:
| Поступила в редакцию: | 26 дек. 2012 г. |
| Принята к публикации: | 25 мар. 2013 г. |
| Опубликована online: | 26 мар. 2013 г. |
Идентификаторы БД:
| Web of science: | WOS:000320466600018 |
| Scopus: | 2-s2.0-84881450706 |
| РИНЦ: | 20454710 |
| Chemical Abstracts: | 2013:952232 |
| Chemical Abstracts (print): | 159:76073 |
| OpenAlex: | W2158702281 |