Simple and Efficient Modifications of Well Known Techniques for Reliable Growth of High-Quality Crystals of Small Bioorganic Molecules Full article
| Journal |
Journal of Applied Crystallography
ISSN: 0021-8898 , E-ISSN: 1600-5767 |
||||
|---|---|---|---|---|---|
| Output data | Year: 2014, Volume: 47, Number: 4, Pages: 1435-1442 Pages count : 8 DOI: 10.1107/S1600576714011273 | ||||
| Tags | crystal growth from solution; X-ray diffraction; Raman spectroscopy; control of nucleation; control of nuclei growth; seeding. | ||||
| Authors |
|
||||
| Affiliations |
|
Abstract:
A number of modifications to traditional techniques are suggested in order to overcome problems that frequently arise when growing crystals from solution. These improvements, and their combination, help to avoid problems such as poor nucleation, the spontaneous precipitation of many poor-quality small powder-like crystals, crystals adhering to the crystallization vessel or to each other, and chemical degradation of the solution. The proposed techniques can be used to crystallize desirable metastable polymorphs reliably. None of the suggested methods demands the usage of any special or expensive equipment, or specific skills, and they can be implemented in the chemistry curriculum even at secondary school level. Examples are given for the crystallization of small organic molecules such as carboxylic acids, amino acids, pharmaceuticals etc., but the same techniques are applicable to other classes of compound.
Cite:
Rychkov D.A.
, Arkhipov S.G.
, Boldyreva E.V.
Simple and Efficient Modifications of Well Known Techniques for Reliable Growth of High-Quality Crystals of Small Bioorganic Molecules
Journal of Applied Crystallography. 2014.
V.47. N4. P.1435-1442. DOI: 10.1107/S1600576714011273
WOS
Scopus
РИНЦ
ANCAN
OpenAlex
Simple and Efficient Modifications of Well Known Techniques for Reliable Growth of High-Quality Crystals of Small Bioorganic Molecules
Journal of Applied Crystallography. 2014.
V.47. N4. P.1435-1442. DOI: 10.1107/S1600576714011273
WOS
Scopus
РИНЦ
ANCAN
OpenAlex
Files:
Full text from publisher
Dates:
| Submitted: | Jan 14, 2014 |
| Accepted: | May 15, 2014 |
| Published online: | Jun 14, 2014 |
| Published print: | Aug 1, 2014 |
Identifiers:
| Web of science: | WOS:000340362000031 |
| Scopus: | 2-s2.0-84905454410 |
| Elibrary: | 23977469 |
| Chemical Abstracts: | 2014:1261031 |
| Chemical Abstracts (print): | 163:265977 |
| OpenAlex: | W2033470409 |