Advances in Elucidating Mechanochemical Complexities via Implementation of a Simple Organic System | Sciact - CRIS-система Института катализа

Advances in Elucidating Mechanochemical Complexities via Implementation of a Simple Organic System Научная публикация

Журнал

Faraday Discussions
ISSN: 1359-6640 , E-ISSN: 1364-5498

Вых. Данные

Год: 2014, Том: 170, Страницы: 311-335 Страниц : 25 DOI: 10.1039/c3fd00150d

Ключевые слова

COCRYSTAL FORMATION; CARBOXYLIC-ACIDS; MOLECULAR-CRYSTALS; CO-CRYSTALS; SOLID-STATE; STRUCTURAL-CHARACTERIZATION; PHARMACEUTICAL COCRYSTALS; PHASE-TRANSFORMATIONS; MECHANICAL ACTIVATION; GLYCINE POLYMORPHISM

Авторы

Michalchuk Adam A.L. ^1,2 , Tumanov Ivan A. ^2,3 , Drebushchak Valeri A. ^2,4 , Boldyreva Elena V. ^2,3

Организации

1	School of Chemistry, The University of Edinburgh, Edinburgh, UK.
2	Novosibirsk State University, Novosibirsk, Russian Federation
3	Institute of Solid State Chemistry and Mechanochemistry SB RAS, Novosibirsk, Russian Federation
4	Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russian Federation

Mechanochemistry is becoming increasingly popular amongst both the academic and industrial communities as an alternative method for inducing physical and chemical reactions. Despite its rapidly expanding application, little is understood of its mechanisms, greatly limiting its capacity. In the present work the application of specialty devices allowed submission of the simple organic system, α-glycine + β-malonic acid, to isolated shearing and impact treatment. In doing so, unique products were observed to result from each of these major mechanical actions; shear inducing formation of the known salt, glycinium semi-malonate (GSM), and impact yielding formation of a novel phase. Correlation of these isolated treatments with a more common ball mill indicated two unique regions within the milling jar, each characterised by varying ratios of shear and impact, leading to different products being observed. It is widely accepted that, particularly when considering organic systems, mechanical treatment often acts by inducing increases in local temperature, leading to volatilisation or melting. A combination of DSC and TGA were used to investigate the role of temperature on the system in question. Invariably, heating induced formation of GSM, with evidence supporting a eutectic melt, rather than a gas-phase reaction. Shear heating alone is unable to describe formation of the novel phase obtained through impact treatment. By considering the formation and character of mechanically produced tablets, a model is described that may account for formation of this novel phase. This system and methodology for mechanochemical study offers intriguing opportunities for continued study of this widely used and exciting field

Michalchuk A.A.L. , Tumanov I.A. , Drebushchak V.A. , Boldyreva E.V.
Advances in Elucidating Mechanochemical Complexities via Implementation of a Simple Organic System
Faraday Discussions. 2014. V.170. P.311-335. DOI: 10.1039/c3fd00150d WOS Scopus РИНЦ CAPlusCA OpenAlex

Поступила в редакцию:	20 дек. 2013 г.
Принята к публикации:	6 февр. 2014 г.
Опубликована online:	6 февр. 2014 г.
Опубликована в печати:	6 февр. 2016 г.

Web of science:	WOS:000345208300020
Scopus:	2-s2.0-84912061204
РИНЦ:	24007423
Chemical Abstracts:	2014:1928319
Chemical Abstracts (print):	162:563821
OpenAlex:	W2014941251

БД	Цитирований
Web of science	42
Scopus	45
OpenAlex	50